Synergistic effect of carnosine on browning of adipose tissue in exercised obese rats; a focus on circulating irisin levels.

Schaalan MF, Ramadan BK, Abd Elwahab AH

Journal of cellular physiology5 Jan 2018Cited by 32 (Europe PMC)

PMID29236301DOI10.1002/jcp.26370PepBankPUB-29236301

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In obese rats, carnosine treatment significantly decreased body weight gain.
In plain wordsIn obese rats, carnosine significantly reduced body weight gain.
Peptide
L-carnosine
Outcome
DecreaseBody weight gain
Study
ratn: not reported in source
high-fat-diet obese male Wistar albino rats
Outcome group
Body weight · Metabolic and weight
Studied dose
250 mg/kg · intraperitoneal · 6 weeksAs given in this study (rat).
Source sentences
Summary
Both exercise training for 6 weeks and carnosine treatment significantly decreased body weight gain, ameliorated obesity-induced dyslipidemia, reduced the thiobarbituric acid reactive species (TBARS) and TNF-α, while increased total antioxidant capacity and IL-10.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to evaluate the effect of L-carnosine on browning of white adipose tissue in exercised obese rats.
Summary · context
(v) HFD rats injected with L-carnosine (250 mg/kg,i.p.) for 6 weeks (HFD/CAR)
Report a problemFND-2923630101
02AnimalAnimal study (in vivo)Efficacy outcome
In obese rats, carnosine treatment significantly ameliorated obesity-induced dyslipidemia.
In plain wordsIn obese rats, carnosine significantly improved abnormal blood lipids.
Peptide
L-carnosine
Outcome
DecreaseDyslipidemia
Study
ratn: not reported in source
high-fat-diet obese male Wistar albino rats
Outcome group
Lipids · Metabolic and weight
Studied dose
250 mg/kg · intraperitoneal · 6 weeksAs given in this study (rat).
Source sentences
Summary
Both exercise training for 6 weeks and carnosine treatment significantly decreased body weight gain, ameliorated obesity-induced dyslipidemia, reduced the thiobarbituric acid reactive species (TBARS) and TNF-α, while increased total antioxidant capacity and IL-10.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to evaluate the effect of L-carnosine on browning of white adipose tissue in exercised obese rats.
Summary · context
(v) HFD rats injected with L-carnosine (250 mg/kg,i.p.) for 6 weeks (HFD/CAR)
Report a problemFND-2923630102
03AnimalAnimal study (in vivo)Efficacy outcome
In obese rats, carnosine treatment significantly reduced TBARS.
In plain wordsIn obese rats, carnosine significantly reduced TBARS.
Peptide
L-carnosine
Outcome
DecreaseTBARS
Study
ratn: not reported in source
high-fat-diet obese male Wistar albino rats
Outcome group
Aging markers · Metabolic and weight
Studied dose
250 mg/kg · intraperitoneal · 6 weeksAs given in this study (rat).
Source sentences
Summary
Both exercise training for 6 weeks and carnosine treatment significantly decreased body weight gain, ameliorated obesity-induced dyslipidemia, reduced the thiobarbituric acid reactive species (TBARS) and TNF-α, while increased total antioxidant capacity and IL-10.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to evaluate the effect of L-carnosine on browning of white adipose tissue in exercised obese rats.
Summary · context
(v) HFD rats injected with L-carnosine (250 mg/kg,i.p.) for 6 weeks (HFD/CAR)
Report a problemFND-2923630103
04AnimalAnimal study (in vivo)Efficacy outcome
In obese rats, carnosine treatment significantly reduced TNF-α.
In plain wordsIn obese rats, carnosine significantly reduced TNF-α.
Peptide
L-carnosine
Outcome
DecreaseTNF-α
Study
ratn: not reported in source
high-fat-diet obese male Wistar albino rats
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
250 mg/kg · intraperitoneal · 6 weeksAs given in this study (rat).
Source sentences
Summary
Both exercise training for 6 weeks and carnosine treatment significantly decreased body weight gain, ameliorated obesity-induced dyslipidemia, reduced the thiobarbituric acid reactive species (TBARS) and TNF-α, while increased total antioxidant capacity and IL-10.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to evaluate the effect of L-carnosine on browning of white adipose tissue in exercised obese rats.
Summary · context
(v) HFD rats injected with L-carnosine (250 mg/kg,i.p.) for 6 weeks (HFD/CAR)
Report a problemFND-2923630104
05AnimalAnimal study (in vivo)Efficacy outcome
In obese rats, carnosine treatment increased total antioxidant capacity.
In plain wordsIn obese rats, carnosine increased total antioxidant capacity.
Peptide
L-carnosine
Outcome
IncreaseTotal antioxidant capacity
Study
ratn: not reported in source
high-fat-diet obese male Wistar albino rats
Outcome group
Aging markers · Metabolic and weight
Studied dose
250 mg/kg · intraperitoneal · 6 weeksAs given in this study (rat).
Source sentences
Summary
Both exercise training for 6 weeks and carnosine treatment significantly decreased body weight gain, ameliorated obesity-induced dyslipidemia, reduced the thiobarbituric acid reactive species (TBARS) and TNF-α, while increased total antioxidant capacity and IL-10.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to evaluate the effect of L-carnosine on browning of white adipose tissue in exercised obese rats.
Summary · context
(v) HFD rats injected with L-carnosine (250 mg/kg,i.p.) for 6 weeks (HFD/CAR)
Report a problemFND-2923630105
06AnimalAnimal study (in vivo)Efficacy outcome
In obese rats, carnosine treatment increased IL-10.
In plain wordsIn obese rats, carnosine increased IL-10.
Peptide
L-carnosine
Outcome
IncreaseIL-10
Study
ratn: not reported in source
high-fat-diet obese male Wistar albino rats
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
250 mg/kg · intraperitoneal · 6 weeksAs given in this study (rat).
Source sentences
Summary
Both exercise training for 6 weeks and carnosine treatment significantly decreased body weight gain, ameliorated obesity-induced dyslipidemia, reduced the thiobarbituric acid reactive species (TBARS) and TNF-α, while increased total antioxidant capacity and IL-10.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to evaluate the effect of L-carnosine on browning of white adipose tissue in exercised obese rats.
Summary · context
(v) HFD rats injected with L-carnosine (250 mg/kg,i.p.) for 6 weeks (HFD/CAR)
Report a problemFND-2923630106

Studies that did not test the peptide alone2

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

07AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In obese rats, combined exercise and carnosine produced the highest physiological improvement among studied groups.
In plain wordsIn obese rats, combined exercise and carnosine produced the greatest physiological improvement among studied groups.
Peptide
L-carnosine
Outcome
IncreaseCombined physiological improvement
Study
ratn: not reported in source
high-fat-diet obese male Wistar albino rats
Outcome group
Exercise and physical function · Metabolic and weight
Source sentences
Summary
The highest improvement was evident in the combined exercise and carnosine group which indicates that their beneficial effects in obese animals were synergistic.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to evaluate the effect of L-carnosine on browning of white adipose tissue in exercised obese rats.
Summary · context
(v) HFD rats injected with L-carnosine (250 mg/kg,i.p.) for 6 weeks (HFD/CAR)
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2923630107
08AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Mechanism
In obese rats, increases in serum irisin, adipose UCP-1, CD137 and p38 MAPK, and muscular FNDC5 correlated with carnosine- and exercise-induced improvements.
In plain wordsIn obese rats, increases in browning-related markers correlated with physiological improvements associated with carnosine and exercise.
Peptide
L-carnosine
Outcome
IncreaseBrowning-related marker increases associated with physiological improvements
Study
ratn: not reported in source
exercised obese rats
Outcome group
Receptor activity and mechanism · Metabolic and weight
Source sentences
Summary
increases in serum irisin levels and the expression of adipose uncoupling protein-1 (UCP-1), adipose CD137, p38 MAPK, and muscular fibronectin type III domain-containing protein 5(FNDC5), the precursor of irisin gene expression, were correlated with these carnosine- and exercise-induced physiological improvements.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2923630108

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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