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Study · Randomized controlled trial · n = 150 · 2018

6 results

Peri-operative management of patients with type-2 diabetes mellitus undergoing non-cardiac surgery using liraglutide, glucose-insulin-potassium infusion or intravenous insulin bolus regimens: a randomised controlled trial.

Polderman JAW, van Steen SCJ, Thiel B, Godfried MB, Houweling PL, Hollmann MW, DeVries JH, Preckel B, Hermanides J

Anaesthesia12 Dec 2017Cited by 45 (Europe PMC)

PMID29230803 (opens in a new tab)DOI10.1111/anae.14180 (opens in a new tab)PepBankPUB-29230803
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing non-cardiac surgery, median plasma glucose 1 h after surgery was lower with liraglutide premedication (6.6 mmol/l) than with insulin infusion (7.5 mmol/l).

    In plain wordsIn adults with type 2 diabetes having surgery, blood sugar an hour after surgery was lower with liraglutide than with an insulin infusion.

    Peptide
    Liraglutide
    Outcome
    DecreasePlasma glucose 1 h after surgery, liraglutide versus insulin infusion
    Study

    n = 97

    Comparator
    Glucose-insulin-potassium infusion
    Analysis
    Primary
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Median plasma glucose 1 h postoperatively
    6.6 mmol/l
    liraglutide

    Source sentences

    Summary
    Median (IQR [range]) plasma glucose 1 h postoperatively was lower in the liraglutide group compared with the insulin infusion and insulin bolus groups (6.6 (5.6-7.7 [4.2-13.5]) mmol.l-1 vs. 7.5 (6.4-8.3 [3.9-16.6]) mmol.l-1 (p = 0.026) and 7.6 (6.4-8.9 [4.7-13.2]) mmol.l-1…
    2 context sentences
    Summary · context
    In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery.
    Summary · context
    We analysed 150 patients (liraglutide group n = 44, insulin infusion group n = 53, insulin bolus group n = 53) according to the intention-to-treat principle.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing non-cardiac surgery, median plasma glucose 1 h after surgery was lower with liraglutide premedication (6.6 mmol/l) than with insulin bolus (7.6 mmol/l).

    In plain wordsIn adults with type 2 diabetes having surgery, blood sugar an hour after surgery was lower with liraglutide than with insulin boluses.

    Peptide
    Liraglutide
    Outcome
    DecreasePlasma glucose 1 h after surgery, liraglutide versus insulin bolus
    Study

    n = 97

    Comparator
    Insulin bolus regimen
    Analysis
    Primary
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Median plasma glucose 1 h postoperatively
    6.6 mmol/l
    liraglutide

    Source sentences

    Summary
    Median (IQR [range]) plasma glucose 1 h postoperatively was lower in the liraglutide group compared with the insulin infusion and insulin bolus groups (6.6 (5.6-7.7 [4.2-13.5]) mmol.l-1 vs. 7.5 (6.4-8.3 [3.9-16.6]) mmol.l-1 (p = 0.026) and 7.6 (6.4-8.9 [4.7-13.2]) mmol.l-1…
    2 context sentences
    Summary · context
    In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery.
    Summary · context
    We analysed 150 patients (liraglutide group n = 44, insulin infusion group n = 53, insulin bolus group n = 53) according to the intention-to-treat principle.
  3. 03HumanRandomized controlled trialSafety outcome

    In adults with type 2 diabetes undergoing non-cardiac surgery, the incidence of hypoglycaemia did not differ between liraglutide and the insulin groups.

    In plain wordsIn adults with type 2 diabetes having surgery, low blood sugar was not more common with liraglutide than with insulin.

    Peptide
    Liraglutide
    Outcome
    No significant changeIncidence of hypoglycaemia
    Study

    n = 150

    Comparator
    Insulin infusion and insulin bolus groups
    Outcome group
    Adverse events · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The incidence of hypoglycaemia and postoperative complications did not differ between the groups.
    2 context sentences
    Summary · context
    In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery.
    Summary · context
    We analysed 150 patients (liraglutide group n = 44, insulin infusion group n = 53, insulin bolus group n = 53) according to the intention-to-treat principle.
  4. 04HumanRandomized controlled trialSafety outcome

    In adults with type 2 diabetes undergoing non-cardiac surgery, the incidence of postoperative complications did not differ between liraglutide and the insulin groups.

    In plain wordsIn adults with type 2 diabetes having surgery, complications after surgery were not more common with liraglutide than with insulin.

    Peptide
    Liraglutide
    Outcome
    No significant changePostoperative complications
    Study

    n = 150

    Comparator
    Insulin infusion and insulin bolus groups
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The incidence of hypoglycaemia and postoperative complications did not differ between the groups.
    2 context sentences
    Summary · context
    In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery.
    Summary · context
    We analysed 150 patients (liraglutide group n = 44, insulin infusion group n = 53, insulin bolus group n = 53) according to the intention-to-treat principle.
  5. 05HumanRandomized controlled trialSafety outcome

    In adults with type 2 diabetes undergoing non-cardiac surgery, six patients in the liraglutide group had pre-operative nausea versus none in the insulin groups.

    In plain wordsIn adults with type 2 diabetes having surgery, nausea before surgery was more common with liraglutide than with insulin.

    Peptide
    Liraglutide
    Outcome
    IncreasePre-operative nausea
    Study

    n = 150

    Comparator
    Insulin infusion and insulin bolus groups
    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Six patients had pre-operative nausea in the liraglutide group, of which two had severe nausea, compared with no patients in the insulin infusion and insulin bolus groups (p = 0.007).
    2 context sentences
    Summary · context
    In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery.
    Summary · context
    We analysed 150 patients (liraglutide group n = 44, insulin infusion group n = 53, insulin bolus group n = 53) according to the intention-to-treat principle.
  6. 06HumanRandomized controlled trialSafety outcome

    In adults with type 2 diabetes undergoing non-cardiac surgery, two patients in the liraglutide group had severe pre-operative nausea versus none in the insulin groups.

    In plain wordsIn adults with type 2 diabetes having surgery, two people had severe nausea before surgery with liraglutide and none with insulin.

    Peptide
    Liraglutide
    Outcome
    IncreaseSevere pre-operative nausea
    Study

    n = 150

    Comparator
    Insulin infusion and insulin bolus groups
    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Measurements

    Patients with severe pre-operative nausea
    2 patients
    liraglutide group

    Source sentences

    Summary
    Six patients had pre-operative nausea in the liraglutide group, of which two had severe nausea, compared with no patients in the insulin infusion and insulin bolus groups (p = 0.007).
    2 context sentences
    Summary · context
    In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery.
    Summary · context
    We analysed 150 patients (liraglutide group n = 44, insulin infusion group n = 53, insulin bolus group n = 53) according to the intention-to-treat principle.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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