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Study · Randomized controlled trial · n = 192 · 2017

4 results

Final follicular maturation by administration of GnRH agonist plus HCG versus HCG in normal responders in ART cycles: An RCT.

Eftekhar M, Mojtahedi MF, Miraj S, Omid M

International journal of reproductive biomedicine1 Jul 2017Cited by 24 (Europe PMC)

PMID29177244 (opens in a new tab)PMCIDPMC5601934 (opens in a new tab)DOI10.29252/ijrm.15.7.429 (opens in a new tab)PepBankPUB-29177244
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Summary

BackgroundGonadotropin-releasing hormone agonists (GnRH-a) was increasingly used for triggering oocyte maturationfor the prevention of ovarian hyperstimulation syndrome. Studies suggest that GnRH-a might be used as a better trigger agent since it causes both Luteinizing hormone and follicle stimulating hormone release from a physiologic natural cycle.ObjectiveThe aim of this study was to evaluate the effect of dual-triggering in assisted reproductive technology outcomes.Materials and methods192 normal responder women aged ≤42 years and 182 enrolled in this single-blind randomized controlled trial. All participants received antagonist protocol. For final triggering, women randomly were divided into two groups. Group, I was triggered by 6500 IU human chorionic gonadotropin (hCG) alone, and group II by 6500 IU hCG plus 0.2 mg of triptorelin. The implantation, chemical, clinical and ongoing pregnancy, and abortion rates were measured.ResultsThe mean of retrieved oocytes and obtained embryos were statistically higher in the dual-trigger group (group I), but the implantation and pregnancy rates were similar in two groups.ConclusionThe results of our study did not confirm the favorable effect of dual-triggered oocyte maturation with a GnRH-a and a standard dosage of hCG as an effective strategy to optimize pregnancy outcome for normal responders in GnRH-antagonist cycles. We think that this new concept requires more studies before becoming a universal controlled ovarian hyperstimulation protocol in in vitro fertilization practice.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In normal responders, triptorelin plus hCG increased retrieved oocytes compared with hCG alone.

    In plain wordsIn normal responders, triptorelin plus hCG increased retrieved oocytes compared with hCG alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseRetrieved oocytes
    Study

    n = 192

    Comparator
    hCG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Source sentences

    Summary
    The mean of retrieved oocytes and obtained embryos were statistically higher in the dual-trigger group (group I), but the implantation and pregnancy rates were similar in two groups.
    2 context sentences
    Summary · context
    192 normal responder women aged ≤42 years and 182 enrolled in this single-blind randomized controlled trial.
    Summary · context
    Group, I was triggered by 6500 IU human chorionic gonadotropin (hCG) alone, and group II by 6500 IU hCG plus 0.2 mg of triptorelin.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In normal responders, triptorelin plus hCG increased obtained embryos compared with hCG alone.

    In plain wordsIn normal responders, triptorelin plus hCG increased obtained embryos compared with hCG alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseObtained embryos
    Study

    n = 192

    Comparator
    hCG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Source sentences

    Summary
    The mean of retrieved oocytes and obtained embryos were statistically higher in the dual-trigger group (group I), but the implantation and pregnancy rates were similar in two groups.
    2 context sentences
    Summary · context
    192 normal responder women aged ≤42 years and 182 enrolled in this single-blind randomized controlled trial.
    Summary · context
    Group, I was triggered by 6500 IU human chorionic gonadotropin (hCG) alone, and group II by 6500 IU hCG plus 0.2 mg of triptorelin.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In normal responders, implantation rates were similar with triptorelin plus hCG and hCG alone.

    In plain wordsIn normal responders, implantation rates were similar with triptorelin plus hCG and hCG alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeImplantation rate
    Study

    n = 192

    Comparator
    hCG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Source sentences

    Summary
    The mean of retrieved oocytes and obtained embryos were statistically higher in the dual-trigger group (group I), but the implantation and pregnancy rates were similar in two groups.
    2 context sentences
    Summary · context
    192 normal responder women aged ≤42 years and 182 enrolled in this single-blind randomized controlled trial.
    Summary · context
    Group, I was triggered by 6500 IU human chorionic gonadotropin (hCG) alone, and group II by 6500 IU hCG plus 0.2 mg of triptorelin.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In normal responders, pregnancy rates were similar with triptorelin plus hCG and hCG alone.

    In plain wordsIn normal responders, pregnancy rates were similar with triptorelin plus hCG and hCG alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePregnancy rate
    Study

    n = 192

    Comparator
    hCG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Source sentences

    Summary
    The mean of retrieved oocytes and obtained embryos were statistically higher in the dual-trigger group (group I), but the implantation and pregnancy rates were similar in two groups.
    2 context sentences
    Summary · context
    192 normal responder women aged ≤42 years and 182 enrolled in this single-blind randomized controlled trial.
    Summary · context
    Group, I was triggered by 6500 IU human chorionic gonadotropin (hCG) alone, and group II by 6500 IU hCG plus 0.2 mg of triptorelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 1 ongoing · source ClinicalTrials.gov (opens in a new tab)

RecruitingNot applicableNCT07861399

Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders

Al-Azhar Universityn = 1001 Sept 2026 to est. Oct 2028

ICSI · IVF · Normal Responders · Infertility Assisted Reproductive Technology · Infertile Women Undergoing IVF or ICSI · Infertile Women Undergoing ART · Triggering Ovulation · Oocyte Maturation

Trial pageClinicalTrials.govUpdated 6 Oct 2026
Status unknownNot applicableNCT04717752

A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve

Nanjing Universityn = 310est. 20 Jan 2021 to est. 31 Dec 2021

Poor Ovarian Response

Trial pageClinicalTrials.govUpdated 28 Jan 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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