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Study · Not a test of the peptide alone · 2018

3 results

A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.

Alam MP, Bilousova T, Spilman P, Vadivel K, Bai D, Elias CJ, Evseenko D, John V

ACS chemical neuroscience6 Dec 2017Cited by 8 (Europe PMC)

PMID29161500 (opens in a new tab)DOI10.1021/acschemneuro.7b00350 (opens in a new tab)PepBankPUB-29161500
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In primary hippocampal neurons, small molecule mimetics that target the Humanin binding site on gp130 protected against NMDA-induced neurotoxicity.

    In plain wordsIn cells, small molecules designed to mimic humanin's binding site protected neurons from NMDA-induced toxicity.

    Peptide
    Humanin
    Outcome
    IncreaseProtection against NMDA-induced neurotoxicity
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    synthesis of small molecule mimetics that interact with the HN binding site on the gp130 receptor and provide protection against NMDA-induced neurotoxicity in primary hippocampal neurons.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneOther designOther

    Exploratory medicinal chemistry identified a brain permeable small molecule mimetic of the Humanin binding site.

    In plain wordsChemistry work found a small molecule that can enter the brain and copies humanin's binding site.

    Peptide
    Humanin
    Outcome
    Not applicableBrain permeable small molecule mimetic identified
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    A brain permeable small molecule mimetic was identified through exploratory medicinal chemistry using microfluidic flow chemistry to facilitate the synthesis of new analogues for screening and SAR optimization.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03Computer modelNot a test of Humanin aloneIn silicoMechanism

    Modeling identified the binding site of Humanin on the extracellular domain of the gp130 receptor.

    In plain wordsComputer modeling located where humanin binds to the gp130 receptor.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin binding site on the gp130 receptor
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We report here for the first time the elucidation of the binding site of Humanin (HN) peptide to the gp130 receptor extracellular domain through modeling

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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