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Study · Animal study (in vivo) · mouse · 2017

9 results

Mitochondria Targeted Peptide Attenuates Mitochondrial Dysfunction, Controls Inflammation and Protects Against Spinal Cord Injury-Induced Lung Injury.

Zhu LL, Li MQ, He F, Zhou SB, Jiang W

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology13 Nov 2017Cited by 26 (Europe PMC)

PMID29132140 (opens in a new tab)DOI10.1159/000484919 (opens in a new tab)PepBankPUB-29132140
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, SS‑31 treatment attenuated lung edema.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment reduced fluid build-up in the lungs.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLung edema
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    SS-31 treatment attenuated lung edema and tissue damage.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, SS‑31 treatment attenuated lung tissue damage.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment reduced damage to lung tissue.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLung tissue damage
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    SS-31 treatment attenuated lung edema and tissue damage.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, SS‑31 treatment reduced apoptosis of alveolar type II cells.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment reduced programmed cell death of a type of lung cell.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseApoptosis of alveolar type II cells
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, SS-31 treatment reduced apoptosis of alveolar type II cells, the number of total macrophages and M1 macrophages, and neutrophil infiltration.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 treatment reduced the number of total macrophages in the lung.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment reduced the number of immune cells (macrophages) in the lungs.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTotal macrophage number in lung
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, SS-31 treatment reduced apoptosis of alveolar type II cells, the number of total macrophages and M1 macrophages, and neutrophil infiltration.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 treatment reduced the number of M1 macrophages in the lung.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment reduced the number of pro-inflammatory (M1) immune cells in the lungs.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseM1 macrophage number in lung
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, SS-31 treatment reduced apoptosis of alveolar type II cells, the number of total macrophages and M1 macrophages, and neutrophil infiltration.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 treatment reduced neutrophil infiltration in the lung.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment reduced the entry of neutrophil immune cells into the lungs.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNeutrophil infiltration in lung
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, SS-31 treatment reduced apoptosis of alveolar type II cells, the number of total macrophages and M1 macrophages, and neutrophil infiltration.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 treatment attenuated reactive oxygen species levels in the lung.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment lowered levels of reactive oxygen species in the lungs.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseReactive oxygen species levels
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, SS-31 treatment attenuated reactive oxygen species levels, reversed mitochondrial dysfunction and inhibited NLRP3 inflammasome activation.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 treatment reversed mitochondrial dysfunction in the lung.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment reversed faulty function of the energy-producing parts of lung cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial dysfunction
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, SS-31 treatment attenuated reactive oxygen species levels, reversed mitochondrial dysfunction and inhibited NLRP3 inflammasome activation.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 treatment inhibited NLRP3 inflammasome activation in the lung.

    In plain wordsIn mice with spinal cord injury, SS‑31 treatment blocked activation of an inflammation complex (NLRP3) in the lungs.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNLRP3 inflammasome activation
    Study

    mousen: not reported in source

    spinal cord injury (SCI)-induced lung injury
    Comparator
    SCI plus vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, SS-31 treatment attenuated reactive oxygen species levels, reversed mitochondrial dysfunction and inhibited NLRP3 inflammasome activation.
    2 context sentences
    Summary · context
    Immediately after injury, mice in the treatment groups received a daily, single-dose intraperitoneal injection of SS-31 and for the next 2 days.
    Summary · context
    The sham and SCI groups also received a daily single dose of vehicle (DMSO and 0.9% NaCl, 1: 3).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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