Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ

Scientific reports8 Nov 2017Cited by 65 (Europe PMC)

PMID29118320PMCIDPMC5678092DOI10.1038/s41598-017-14866-zPepBankPUB-29118320

Summary

Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD⁺). We have shown that the NAD⁺ precursor, nicotinamide mononucleotide (NMN) can reverse some of the negative consequences of high fat diet (HFD) consumption. To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers. Five week old lean and obese female C57BL6/J mice were mated with chow fed males. Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN injection daily for 18 days. Maternal obesity programmed increased adiposity and liver triglycerides, with decreased glucose tolerance, liver NAD⁺ levels and citrate synthase activity in offspring. Both interventions reduced adiposity, and showed a modest improvement in glucose tolerance and improved markers of mitochondrial function. NMN appeared to have stronger effects on liver fat catabolism (Hadh) and synthesis (Fasn) than exercise. The interventions appeared to exert the most global benefit in mice that were most metabolically challenged (HFD-consuming offspring of obese mothers). This work encourages further study to confirm the suitability of NMN for use in reversing metabolic dysfunction linked to programming by maternal obesity.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female mouse offspring studied for maternal obesity effects, NMN reduced adiposity.
In plain wordsIn mice studied for maternal obesity effects, NMN reduced body fat.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseAdiposity
Study
mousen: not reported in source
female high-fat-fed offspring of lean and obese mothers
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · injection · 18 daysAs given in this study (mouse).
Source sentences
Summary
Both interventions reduced adiposity, and showed a modest improvement in glucose tolerance and improved markers of mitochondrial function.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers.
Summary · context
Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN injection daily for 18 days.
Show in the study text Report a problemFND-2911832001
02AnimalAnimal study (in vivo)Efficacy outcome
In female mouse offspring studied for maternal obesity effects, NMN modestly improved glucose tolerance.
In plain wordsIn mice studied for maternal obesity effects, NMN modestly improved glucose tolerance.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGlucose tolerance
Study
mousen: not reported in source
female high-fat-fed offspring of lean and obese mothers
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · injection · 18 daysAs given in this study (mouse).
Source sentences
Summary
Both interventions reduced adiposity, and showed a modest improvement in glucose tolerance and improved markers of mitochondrial function.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers.
Summary · context
Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN injection daily for 18 days.
Show in the study text Report a problemFND-2911832002
03AnimalAnimal study (in vivo)Mechanism
In female mouse offspring studied for maternal obesity effects, NMN improved markers of mitochondrial function.
In plain wordsIn mice studied for maternal obesity effects, NMN improved markers of mitochondrial function.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMarkers of mitochondrial function
Study
mousen: not reported in source
female high-fat-fed offspring of lean and obese mothers
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated · injection · 18 daysAs given in this study (mouse).
Source sentences
Summary
Both interventions reduced adiposity, and showed a modest improvement in glucose tolerance and improved markers of mitochondrial function.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers.
Summary · context
Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN injection daily for 18 days.
Show in the study text Report a problemFND-2911832003
04AnimalAnimal study (in vivo)Mechanism
In female mouse offspring, NMN appeared to affect liver fat catabolism marker Hadh more strongly than exercise.
In plain wordsIn mice, NMN appeared to affect the liver fat breakdown marker Hadh more strongly than exercise.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedLiver fat catabolism marker Hadh
Study
mousen: not reported in source
female high-fat-fed offspring of lean and obese mothers
Comparator
exercise
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · injection · 18 daysAs given in this study (mouse).
Source sentences
Summary
NMN appeared to have stronger effects on liver fat catabolism (Hadh) and synthesis (Fasn) than exercise.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers.
Summary · context
Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN injection daily for 18 days.
Show in the study text Report a problemFND-2911832004
05AnimalAnimal study (in vivo)Mechanism
In female mouse offspring, NMN appeared to affect liver fat synthesis marker Fasn more strongly than exercise.
In plain wordsIn mice, NMN appeared to affect the liver fat synthesis marker Fasn more strongly than exercise.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedLiver fat synthesis marker Fasn
Study
mousen: not reported in source
female high-fat-fed offspring of lean and obese mothers
Comparator
exercise
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · injection · 18 daysAs given in this study (mouse).
Source sentences
Summary
NMN appeared to have stronger effects on liver fat catabolism (Hadh) and synthesis (Fasn) than exercise.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers.
Summary · context
Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN injection daily for 18 days.
Show in the study text Report a problemFND-2911832005
06AnimalAnimal study (in vivo)Efficacy outcome
In mice, NMN appeared to confer the most global benefit in high-fat-fed offspring of obese mothers.
In plain wordsIn mice, NMN appeared to provide the greatest overall benefit in high-fat-fed offspring of obese mothers.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedOverall metabolic benefit by metabolic challenge
Study
mousen: not reported in source
female high-fat-fed offspring of lean and obese mothers
Outcome group
Metabolic pathways and metabolomics · Metabolic and weight
Studied dose
Dose not stated · injection · 18 daysAs given in this study (mouse).
Source sentences
Summary
The interventions appeared to exert the most global benefit in mice that were most metabolically challenged (HFD-consuming offspring of obese mothers).
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers.
Summary · context
Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN injection daily for 18 days.
Show in the study text Report a problemFND-2911832006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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