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Study · Animal study (in vivo) · mouse · 2017

8 results

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.

Baggio LL, Ussher JR, McLean BA, Cao X, Kabir MG, Mulvihill EE, Mighiu AS, Zhang H, Ludwig A, Seeley RJ, Heximer SP, Drucker DJ

Molecular metabolism1 Sept 2017Cited by 98 (Europe PMC)

PMID29107282 (opens in a new tab)PMCIDPMC5681270 (opens in a new tab)DOI10.1016/j.molmet.2017.08.010 (opens in a new tab)PepBankPUB-29107282
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In WT and cardiomyocyte GLP-1R-disrupted mice, liraglutide rapidly increased heart rate.

    In plain wordsIn mice, liraglutide rapidly increased heart rate in both tested genotypes.

    Peptide
    Liraglutide
    Outcome
    IncreaseAcute heart rate
    Study

    mousen: not reported in source

    WT and cardiomyocyte GLP-1R-disrupted mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Doses of liraglutide and lixisenatide that were equipotent for acute glucose control rapidly increased HR in WT and Glp1rCM-/- mice in vivo.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In WT and cardiomyocyte GLP-1R-disrupted mice, lixisenatide rapidly increased heart rate.

    In plain wordsIn mice, lixisenatide rapidly increased heart rate in both tested genotypes.

    Peptide
    Lixisenatide
    Outcome
    IncreaseAcute heart rate
    Study

    mousen: not reported in source

    WT and cardiomyocyte GLP-1R-disrupted mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Doses of liraglutide and lixisenatide that were equipotent for acute glucose control rapidly increased HR in WT and Glp1rCM-/- mice in vivo.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, liraglutide increased heart rate more persistently than lixisenatide.

    In plain wordsIn mice, liraglutide increased heart rate for longer than lixisenatide.

    Peptide
    Liraglutide
    Outcome
    IncreasePersistence of heart-rate increase
    Study

    mousen: not reported in source

    Mice
    Comparator
    Lixisenatide
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The actions of liraglutide to increase HR were more sustained relative to lixisenatide, and diminished in Glp1rCM-/- mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, lixisenatide increased heart rate less persistently than liraglutide.

    In plain wordsIn mice, lixisenatide increased heart rate for less time than liraglutide.

    Peptide
    Lixisenatide
    Outcome
    DecreasePersistence of heart-rate increase
    Study

    mousen: not reported in source

    Mice
    Comparator
    Liraglutide
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The actions of liraglutide to increase HR were more sustained relative to lixisenatide, and diminished in Glp1rCM-/- mice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with cardiomyocyte GLP-1R disruption, the heart-rate response to liraglutide diminished.

    In plain wordsIn mice with disrupted heart-cell GLP-1 receptors, liraglutide produced a smaller heart-rate response than in normal mice.

    Peptide
    Liraglutide
    Outcome
    DecreaseHeart-rate response with cardiac receptor disruption
    Study

    mousen: not reported in source

    Cardiomyocyte GLP-1R-disrupted mice
    Comparator
    WT mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The actions of liraglutide to increase HR were more sustained relative to lixisenatide, and diminished in Glp1rCM-/- mice.
    1 context sentence
    Summary · context
    The actions of GLP-1R agonists were examined on the control of HR in wild type mice (WT) and in mice with cardiomyocyte-selective disruption of the GLP-1R (Glp1rCM-/-).
  6. 06LabEx vivo tissueMechanism

    In isolated mouse hearts, lixisenatide did not increase heart rate.

    In plain wordsIn lab tests on mouse hearts, lixisenatide did not increase heart rate.

    Peptide
    Lixisenatide
    Outcome
    No significant changeEx vivo heart rate
    Study

    mousen: not reported in source

    Isolated perfused mouse hearts
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither native GLP-1 nor lixisenatide increased HR or developed pressure in perfused hearts ex vivo.
  7. 07LabEx vivo tissueMechanism

    In isolated mouse hearts, lixisenatide did not increase developed pressure.

    In plain wordsIn lab tests on mouse hearts, lixisenatide did not increase developed pressure.

    Peptide
    Lixisenatide
    Outcome
    No significant changeVentricular developed pressure
    Study

    mousen: not reported in source

    Isolated perfused mouse hearts
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither native GLP-1 nor lixisenatide increased HR or developed pressure in perfused hearts ex vivo.
  8. 08LabEx vivo tissueMechanism

    In isolated mouse atrial preparations, liraglutide had no direct effect on sinoatrial node firing rate.

    In plain wordsIn lab tests on mouse atrial tissue, liraglutide did not directly change the heart pacemaker firing rate.

    Peptide
    Liraglutide
    Outcome
    No significant changeSinoatrial node firing rate
    Study

    mousen: not reported in source

    Mouse atrial preparations
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, liraglutide had no direct effect on sinoatrial node firing rate in mouse atrial preparations ex vivo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:36 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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