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Study · Animal study (in vivo) · rat · 2018

4 results

The Protective Effect of Cortexin on Cisplatin-Induced Ototoxicity.

Eroğlu O, Karlıdağ T, Kuloğlu T, Keleş E, Kaygusuz İ, Yalçın Ş

The journal of international advanced otology2 Nov 2017Cited by 2 (Europe PMC)

PMID29092803 (opens in a new tab)PMCIDPMC6354512 (opens in a new tab)DOI10.5152/iao.2017.3825 (opens in a new tab)PepBankPUB-29092803
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Cortexin reduced cisplatin-associated emission loss versus cisplatin alone at both assessments, with a larger difference on the eighth day.

    In plain wordsIn rats, Cortexin reduced emission loss versus cisplatin alone, with a larger difference on the eighth day.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseOtoacoustic emission loss versus cisplatin alone
    Study

    ratn: not reported in source

    Cisplatin-induced ototoxicity
    Comparator
    Cisplatin alone
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    2 mg/day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Comparison of Groups II with III showed that emission loss was higher in Group II at both time points, and the difference was more pronounced on the eighth day.
    2 context sentences
    Summary · context
    The study was performed on 30 healthy adult Wistar Albino rats, and rats were randomly divided into three groups of ten.
    Summary · context
    Group III (Cisplatin + Cortexin group) was given ip cisplatin for 2 days at same doses with ip cortexin 2 mg/day for 7 days.

Studies that did not test the peptide alone3

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

  1. 02AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome

    In rats, cisplatin with Cortexin and cisplatin alone raised hearing thresholds versus saline controls on the fourth and eighth days.

    In plain wordsIn rats, hearing thresholds increased with cisplatin plus Cortexin and cisplatin alone versus saline controls.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseAuditory brainstem response hearing thresholds
    Study

    ratn: not reported in source

    Cisplatin-induced ototoxicity
    Comparator
    Saline control
    Outcome group
    Sensory perception · Nervous system and cognition

    Source sentences

    Summary
    ABR tests on the fourth and eighth days showed elevations in the mean hearing thresholds of Groups II and III compared to Group I (p < 0.05).
    2 context sentences
    Summary · context
    The study was performed on 30 healthy adult Wistar Albino rats, and rats were randomly divided into three groups of ten.
    Summary · context
    Group III (Cisplatin + Cortexin group) was given ip cisplatin for 2 days at same doses with ip cortexin 2 mg/day for 7 days.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  2. 03AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome

    In rats, emission values fell from baseline with cisplatin plus Cortexin and cisplatin alone at both assessments.

    In plain wordsIn rats, emission values fell from baseline with cisplatin plus Cortexin and cisplatin alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseOtoacoustic emission loss from baseline
    Study

    ratn: not reported in source

    Cisplatin-induced ototoxicity
    Outcome group
    Sensory perception · Nervous system and cognition

    Source sentences

    Summary
    DPOAE tests revealed a loss in emission values on the fourth and eighth days of the study compared to the baseline in Groups II and III.
    2 context sentences
    Summary · context
    The study was performed on 30 healthy adult Wistar Albino rats, and rats were randomly divided into three groups of ten.
    Summary · context
    Group III (Cisplatin + Cortexin group) was given ip cisplatin for 2 days at same doses with ip cortexin 2 mg/day for 7 days.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  3. 04AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Other

    In rats studied for cisplatin ototoxicity, cochlear histopathological findings supported the auditory test results, without separate histological details.

    In plain wordsIn rats, cochlear tissue findings supported the hearing test results, without separate tissue results.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedHistopathological findings supporting auditory tests
    Study

    ratn: not reported in source

    Cisplatin-induced ototoxicity
    Outcome group
    Sensory perception · Nervous system and cognition

    Source sentences

    Summary
    Histopathological findings supported these tests.
    3 context sentences
    Summary · context
    At the end of fourth day, half of the subjects in all three groups were decapitated, and their cochlea were removed for histopathologic examination.
    Summary · context
    On the eighth day, tests of the remaining subjects and histopathological examinations were repeated.
    Summary · context
    The study was performed on 30 healthy adult Wistar Albino rats, and rats were randomly divided into three groups of ten.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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