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Study · Not a test of the peptide alone · 2017

5 results

Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People.

Katakura Y, Totsuka M, Imabayashi E, Matsuda H, Hisatsune T

Nutrients31 Oct 2017Cited by 52 (Europe PMC)

PMID29088099 (opens in a new tab)PMCIDPMC5707671 (opens in a new tab)DOI10.3390/nu9111199 (opens in a new tab)PepBankPUB-29088099
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Summary

Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1). Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study. The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months. A microarray analysis and subsequent quantitative real-time polymerase chain reaction (qRT-PCR) analysis of peripheral blood mononuclear cells (PBMCs) showed decreased expression of CCL24, an inflammatory chemokine (p < 0.05). Verbal memory, assessed using the Wechsler memory scale-logical memory, was preserved in the ACS group. An age-restricted sub-analysis showed significant verbal memory preservation by ACS in participants who were in their 60s (active, n = 12; placebo, n = 9; p = 0.048) and 70s (active, n = 7; placebo, n = 11; p = 0.017). The suppression of CCL24 expression was greatest in people who were in their 70s (p < 0.01). There was a significant correlation between the preservation of verbal memory and suppression of CCL24 expression in the group that was in the 70s (Poisson correlation, r = 0.46, p < 0.05). These results suggest that ACS may preserve verbal episodic memory, probably owing to CCL24 suppression in the blood, especially in elderly participants.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 01HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In elderly volunteers, anserine/carnosine supplementation decreased PBMC CCL24 expression versus placebo.

    In plain wordsIn elderly volunteers, the anserine/carnosine combination reduced blood-cell CCL24 expression compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseCCL24 expression
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    A microarray analysis and subsequent quantitative real-time polymerase chain reaction (qRT-PCR) analysis of peripheral blood mononuclear cells (PBMCs) showed decreased expression of CCL24, an inflammatory chemokine (p < 0.05).
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1).
    Summary · context
    Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study.
    Summary · context
    The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 02HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In elderly volunteers, anserine/carnosine supplementation preserved verbal memory versus placebo.

    In plain wordsIn elderly volunteers, the anserine/carnosine combination preserved verbal memory compared with placebo.

    Peptide
    L-carnosine
    Outcome
    Not applicableVerbal memory
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Verbal memory, assessed using the Wechsler memory scale-logical memory, was preserved in the ACS group.
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1).
    Summary · context
    Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study.
    Summary · context
    The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 03HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In participants in their 60s, anserine/carnosine supplementation significantly preserved verbal memory versus placebo.

    In plain wordsIn participants in their 60s, the anserine/carnosine combination preserved verbal memory compared with placebo.

    Peptide
    L-carnosine
    Outcome
    Not applicableVerbal memory in participants in their 60s
    Study

    n = 21

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    An age-restricted sub-analysis showed significant verbal memory preservation by ACS in participants who were in their 60s (active, n = 12; placebo, n = 9; p = 0.048) and 70s (active, n = 7; placebo, n = 11; p = 0.017).
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1).
    Summary · context
    Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study.
    Summary · context
    The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  4. 04HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In participants in their 70s, anserine/carnosine supplementation significantly preserved verbal memory versus placebo.

    In plain wordsIn participants in their 70s, the anserine/carnosine combination preserved verbal memory compared with placebo.

    Peptide
    L-carnosine
    Outcome
    Not applicableVerbal memory in participants in their 70s
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    An age-restricted sub-analysis showed significant verbal memory preservation by ACS in participants who were in their 60s (active, n = 12; placebo, n = 9; p = 0.048) and 70s (active, n = 7; placebo, n = 11; p = 0.017).
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1).
    Summary · context
    Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study.
    Summary · context
    The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  5. 05HumanNot a test of L-carnosine aloneObservational studyEfficacy outcome

    In elderly volunteers receiving anserine/carnosine supplementation, CCL24 expression suppression was greatest in participants in their 70s.

    In plain wordsIn elderly volunteers receiving the combination, CCL24 suppression was greatest in participants in their 70s.

    Peptide
    L-carnosine
    Outcome
    DecreaseCCL24 suppression by age
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The suppression of CCL24 expression was greatest in people who were in their 70s (p < 0.01).
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1).
    Summary · context
    Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study.
    Summary · context
    The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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