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Study · Animal study (in vivo) · mouse · 2017

4 results

Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.

Murakami M, Nagahama M, Abe Y, Niikura T

Neuropeptides14 Oct 2017Cited by 15 (Europe PMC)

PMID29070438 (opens in a new tab)DOI10.1016/j.npep.2017.10.002 (opens in a new tab)PepBankPUB-29070438
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cuprizone-treated mice, one week of intraperitoneal HNG improved object recognition memory.

    In plain wordsIn mice given cuprizone, a week of HNG injections improved object recognition memory.

    Peptide
    Humanin
    Outcome
    IncreaseObject recognition memory
    Study

    mousen: not reported in source

    short-term cuprizone (CPZ)-treated mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · one weekAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of HNG for one week improved object recognition memory but not working memory in CPZ-treated mice.
    1 context sentence
    Summary · context
    We tested the effect of HNG on these short-term responses to CZP in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cuprizone-treated mice, one week of intraperitoneal HNG did not improve working memory.

    In plain wordsIn mice given cuprizone, a week of HNG injections did not improve working memory.

    Peptide
    Humanin
    Outcome
    No significant changeWorking memory
    Study

    mousen: not reported in source

    short-term cuprizone (CPZ)-treated mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · one weekAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of HNG for one week improved object recognition memory but not working memory in CPZ-treated mice.
    1 context sentence
    Summary · context
    We tested the effect of HNG on these short-term responses to CZP in mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In cuprizone-treated mice, HNG significantly suppressed CPZ-induced activation of microglia.

    In plain wordsIn mice given cuprizone, HNG reduced the activation of immune cells in the brain.

    Peptide
    Humanin
    Outcome
    DecreaseCPZ-induced microglia activation
    Study

    mousen: not reported in source

    short-term cuprizone (CPZ)-treated mice
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · one weekAs given in this study (mouse).

    Source sentences

    Summary
    Quantitative PCR analyses showed that HNG significantly suppressed CPZ-induced activation of microglia, but did not alter the reduced level of a myelin-specific transcript.
    1 context sentence
    Summary · context
    We tested the effect of HNG on these short-term responses to CZP in mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In cuprizone-treated mice, HNG did not alter the reduced level of a myelin-specific transcript.

    In plain wordsIn mice given cuprizone, HNG did not change the lowered level of a myelin-related transcript.

    Peptide
    Humanin
    Outcome
    No significant changeMyelin-specific transcript level
    Study

    mousen: not reported in source

    short-term cuprizone (CPZ)-treated mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · one weekAs given in this study (mouse).

    Source sentences

    Summary
    Quantitative PCR analyses showed that HNG significantly suppressed CPZ-induced activation of microglia, but did not alter the reduced level of a myelin-specific transcript.
    1 context sentence
    Summary · context
    We tested the effect of HNG on these short-term responses to CZP in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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