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Study · Animal study (in vivo) · mouse · 2018

7 results

S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.

Han K, Jia N, Zhong Y, Shang X

Journal of cellular biochemistry26 Dec 2017Cited by 42 (Europe PMC)

PMID29058763 (opens in a new tab)DOI10.1002/jcb.26452 (opens in a new tab)PepBankPUB-29058763
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In APP/PS1 transgenic mice, HNG improved learning ability and memory.

    In plain wordsIn Alzheimer's model mice, HNG improved learning and memory.

    Peptide
    Humanin
    Outcome
    IncreaseLearning ability and memory
    Study

    mousen: not reported in source

    APP/PS1 transgenic mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results demonstrated that HNG could improve the learning ability and memory in APP/PS1 transgenic mice, possibly through decreasing IRS-1 Ser636 phosphorylation and mTOR protein expression in the hippocampus, thus improving insulin resistance in the brain.
    1 context sentence
    Summary · context
    In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In APP/PS1 mice, HNG possibly decreased IRS-1 Ser636 phosphorylation in the hippocampus, improving brain insulin resistance.

    In plain wordsIn Alzheimer's model mice, HNG lowered a marker of brain insulin resistance in the hippocampus.

    Peptide
    Humanin
    Outcome
    DecreaseIRS-1 Ser636 phosphorylation in hippocampus
    Study

    mousen: not reported in source

    APP/PS1 transgenic mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results demonstrated that HNG could improve the learning ability and memory in APP/PS1 transgenic mice, possibly through decreasing IRS-1 Ser636 phosphorylation and mTOR protein expression in the hippocampus, thus improving insulin resistance in the brain.
    1 context sentence
    Summary · context
    In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In APP/PS1 mice, HNG possibly decreased mTOR protein expression in the hippocampus.

    In plain wordsIn Alzheimer's model mice, HNG lowered mTOR protein in the hippocampus.

    Peptide
    Humanin
    Outcome
    DecreasemTOR protein expression in hippocampus
    Study

    mousen: not reported in source

    APP/PS1 transgenic mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results demonstrated that HNG could improve the learning ability and memory in APP/PS1 transgenic mice, possibly through decreasing IRS-1 Ser636 phosphorylation and mTOR protein expression in the hippocampus, thus improving insulin resistance in the brain.
    1 context sentence
    Summary · context
    In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In APP/PS1 mice, HNG increased ULK1 expression, enhancing autophagy.

    In plain wordsIn Alzheimer's model mice, HNG raised ULK1, a protein that starts autophagy.

    Peptide
    Humanin
    Outcome
    IncreaseULK1 expression
    Study

    mousen: not reported in source

    APP/PS1 transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HNG increased ULK1 expression, decreased p62 and LC3 I/LC3 II protein levels, thus enhancing autophagy and decreasing Aβ deposition in the brain.
    1 context sentence
    Summary · context
    In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In APP/PS1 mice, HNG decreased p62 protein levels, enhancing autophagy.

    In plain wordsIn Alzheimer's model mice, HNG lowered p62, a marker of autophagy.

    Peptide
    Humanin
    Outcome
    Decreasep62 protein level
    Study

    mousen: not reported in source

    APP/PS1 transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HNG increased ULK1 expression, decreased p62 and LC3 I/LC3 II protein levels, thus enhancing autophagy and decreasing Aβ deposition in the brain.
    1 context sentence
    Summary · context
    In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In APP/PS1 mice, HNG decreased LC3 I/LC3 II protein levels, enhancing autophagy.

    In plain wordsIn Alzheimer's model mice, HNG lowered LC3 I/LC3 II, markers of autophagy.

    Peptide
    Humanin
    Outcome
    DecreaseLC3 I/LC3 II protein levels
    Study

    mousen: not reported in source

    APP/PS1 transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HNG increased ULK1 expression, decreased p62 and LC3 I/LC3 II protein levels, thus enhancing autophagy and decreasing Aβ deposition in the brain.
    1 context sentence
    Summary · context
    In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In APP/PS1 mice, HNG decreased Abeta deposition in the brain.

    In plain wordsIn Alzheimer's model mice, HNG reduced amyloid-beta deposits in the brain.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta deposition in the brain
    Study

    mousen: not reported in source

    APP/PS1 transgenic mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HNG increased ULK1 expression, decreased p62 and LC3 I/LC3 II protein levels, thus enhancing autophagy and decreasing Aβ deposition in the brain.
    1 context sentence
    Summary · context
    In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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