[Peptidergic nootropic therapy in cerebral palsy associated with epilepsy].

Kholin AA, Zavadenko NN, Il Ina ES, Kolpakchi LM, Fedonyuk ID, Bembeeva RC, Esipova ES

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2017Cited by 1 (Europe PMC)

PMID29053119DOI10.17116/jnevro20171179137-42PepBankPUB-29053119

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

01HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome
In children with cerebral palsy and epilepsy receiving antiepileptic drugs, add-on Cortexin was followed by a more than twofold reduction in seizures together with improved motor function in 31 patients (36.9%).
In plain wordsIn children with cerebral palsy and epilepsy on seizure drugs, add-on Cortexin came with over twofold fewer seizures and better movement in 31 patients.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseSeizure reduction (>2-fold) with motor improvement
Study
n = 84
Outcome group
Seizures · Nervous system and cognition
Measurements
Patients with seizure reduction and motor improvement
31 patients
Cortexin with AEDs
Patients with seizure reduction and motor improvement
36.9%
Cortexin with AEDs
Source sentences
Summary
Cortexin as add-on to AEDs reduced for more than two times the number of seizures, along with improvement of motor function, in 31 (36.9%) patients.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-four patients (55 boys and 29 girls), aged from 1 to 11 years, with CP combined with epilepsy received cortexin together with antiepileptic drugs (AEDs).
Summary · context
Cortexin was administered in doses of 5-10 mg depending on the patient's age and body weight intramuscularly during hospitalization.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-2905311901
02HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome
In children with cerebral palsy and epilepsy receiving antiepileptic drugs, add-on Cortexin was followed by improved motor function without a significant decrease in seizures in 15 patients (17.8%).
In plain wordsIn children with cerebral palsy and epilepsy on seizure drugs, 15 patients moved better after add-on Cortexin, but their seizures did not clearly drop.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseMotor improvement without significant seizure reduction
Study
n = 84
Outcome group
Exercise and physical function · Nervous system and cognition
Measurements
Motor-only responders
15 patients
Cortexin with AEDs
Motor-only responders
17.8%
Cortexin with AEDs
Source sentences
Summary
The improvement of motor function, but without a significant decrease in epileptic seizures, was achieved in 15 (17.8%) of the patients.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-four patients (55 boys and 29 girls), aged from 1 to 11 years, with CP combined with epilepsy received cortexin together with antiepileptic drugs (AEDs).
Summary · context
Cortexin was administered in doses of 5-10 mg depending on the patient's age and body weight intramuscularly during hospitalization.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-2905311903
03HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome
In children with cerebral palsy and epilepsy receiving antiepileptic drugs, add-on Cortexin was followed by a more than twofold seizure reduction without a significant effect on motor function in 14 patients (16.7%).
In plain wordsIn children with cerebral palsy and epilepsy on seizure drugs, 14 patients had over twofold fewer seizures after add-on Cortexin, with no clear movement change.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseSeizure reduction without significant motor effect
Study
n = 84
Outcome group
Seizures · Nervous system and cognition
Measurements
Seizure-only responders
14 cases
Cortexin with AEDs
Seizure-only responders
16.7%
Cortexin with AEDs
Source sentences
Summary
Reduction of epileptic seizures frequency (>2 times), but without a significant effect on motor function, was observed in 14 cases (16.7%).
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-four patients (55 boys and 29 girls), aged from 1 to 11 years, with CP combined with epilepsy received cortexin together with antiepileptic drugs (AEDs).
Summary · context
Cortexin was administered in doses of 5-10 mg depending on the patient's age and body weight intramuscularly during hospitalization.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-2905311905
04HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome
In children with cerebral palsy and epilepsy receiving antiepileptic drugs, twenty-three patients (27.4%) did not respond to add-on Cortexin.
In plain wordsIn children with cerebral palsy and epilepsy on seizure drugs, twenty-three patients did not respond to add-on Cortexin.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
Direction not reportedNonresponse
Study
n = 84
Outcome group
Seizures · Nervous system and cognition
Measurements
Nonresponders
23 patients
add-on Cortexin with AEDs
Nonresponders
27.4%
add-on Cortexin with AEDs
Source sentences
Summary
Twenty-three patients (27.4%) did not respond the therapy.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-four patients (55 boys and 29 girls), aged from 1 to 11 years, with CP combined with epilepsy received cortexin together with antiepileptic drugs (AEDs).
Summary · context
Cortexin was administered in doses of 5-10 mg depending on the patient's age and body weight intramuscularly during hospitalization.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-2905311907
05HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialSafety outcome
In children with cerebral palsy and epilepsy receiving antiepileptic drugs, seizure aggravation occurred in 1 girl (1.2%) during add-on Cortexin, significantly lower than the probability of aggravation on AED.
In plain wordsIn children with cerebral palsy and epilepsy, one girl's seizures worsened during add-on Cortexin, reported as less likely than worsening on seizure drugs.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseSeizure aggravation
Study
n = 84
Comparator
Probability of aggravation on AED
Outcome group
Adverse events · Nervous system and cognition
Measurements
Seizure aggravation
1 girl
West syndrome
Seizure aggravation
1.2%
Cortexin therapy
Source sentences
Summary
The aggravation of epileptic seizures during cortexin therapy was observed in only 1 girl with West syndrome (1.2%), and this was significantly lower than the probability of seizures aggravation on AED.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-four patients (55 boys and 29 girls), aged from 1 to 11 years, with CP combined with epilepsy received cortexin together with antiepileptic drugs (AEDs).
Summary · context
Cortexin was administered in doses of 5-10 mg depending on the patient's age and body weight intramuscularly during hospitalization.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-2905311908

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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