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Study · In vitro (cells) · 2018

4 results

KiSS1 gene as a novel mediator of TGFβ-mediated cell invasion in triple negative breast cancer.

Tian J, Al-Odaini AA, Wang Y, Korah J, Dai M, Xiao L, Ali S, Lebrun JJ

Cellular signalling6 Oct 2017Cited by 21 (Europe PMC)

PMID28988968 (opens in a new tab)DOI10.1016/j.cellsig.2017.10.002 (opens in a new tab)PepBankPUB-28988968
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In triple negative breast cancer cells, kisspeptin‑10 stimulated cancer cell invasive behavior.

    In plain wordsIn lab-grown breast cancer cells, kisspeptin‑10 made the cells more invasive.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCancer cell invasive behavior
    Study

    n: not reported in source

    Triple negative breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, Kisspeptin-10 (KP-10), the smallest active form of kisspeptin also stimulates cancer cell invasive behavior through activation of MAPK/Erk pathway.
    1 context sentence
    Summary · context
    Here, we identified the kisspeptin KiSS1 as a downstream target of canonical TGFβ/Smad2 pathway in triple negative breast cancer cells.
  2. 02LabIn vitro (cells)Mechanism

    In triple negative breast cancer cells, kisspeptin‑10 stimulated invasion through activation of the MAPK/Erk pathway.

    In plain wordsIn lab-grown breast cancer cells, kisspeptin‑10 acted through the MAPK/Erk signal pathway to increase invasion.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMAPK/Erk pathway activation
    Study

    n: not reported in source

    Triple negative breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, Kisspeptin-10 (KP-10), the smallest active form of kisspeptin also stimulates cancer cell invasive behavior through activation of MAPK/Erk pathway.
    1 context sentence
    Summary · context
    Here, we identified the kisspeptin KiSS1 as a downstream target of canonical TGFβ/Smad2 pathway in triple negative breast cancer cells.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03HumanEndogenous levelObservational studyOther

    In triple negative breast cancer, high KiSS1 expression correlated with lymph node positive status.

    In plain wordsIn triple negative breast cancer, high natural KiSS1 gene activity was linked to cancer in the lymph nodes.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKiSS1 expression and lymph node status
    Study

    n: not reported in source

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    We found KiSS1 high expression to correlate with lymph node positive status.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 04LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In triple negative breast cancer cells, knockdown of KiSS1 expression blocked TGFβ-mediated invasion and MMP9 expression and activity.

    In plain wordsIn lab-grown breast cancer cells, switching off the KiSS1 gene blocked TGFβ-driven invasion.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTGFb-mediated invasion after KiSS1 knockdown
    Study

    n: not reported in source

    Triple negative breast cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Indeed, knockdown expression of KiSS1 blocked TGFβ-mediated cancer cell invasion as well as metalloproteinase (MMP9) expression and activity.
    1 context sentence
    Summary · context
    Here, we identified the kisspeptin KiSS1 as a downstream target of canonical TGFβ/Smad2 pathway in triple negative breast cancer cells.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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