In pubertal female rhesus monkeys, the NK3R antagonist SB222200 blocked kisspeptin-induced GnRH release; it did not block it in prepubertal monkeys.
In plain wordsIn female monkeys, a blocker of the NKB receptor stopped kisspeptin-induced GnRH release after puberty, not before.
- Peptide
- Kisspeptin-10
- Outcome
- DecreaseKisspeptin-induced GnRH release with NK3R antagonist
- Study
rhesus monkeyn: not reported in source
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
Source sentences
(3) the kisspeptin-induced GnRH release was blocked in the presence of the NK3R antagonist SB222200 in the pubertal but not prepubertal monkeys.
1 context sentence(design, population, supporting numbers)
In this study, we conducted a series of experiments infusing agonists and antagonists of kisspeptin and NKB into the stalk-median eminence, where GnRH, kisspeptin, and NKB neuroterminal fibers are concentrated, and measuring GnRH release in prepubertal and pubertal female rhesus monkeys.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.