Skip to content

Study · Animal study (in vivo) · rat · 2013

5 results

[Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of different age].

Mendzheritski AM, Karantysh GV, Abramchuk VA, Ryzhak GA

Advances in gerontology = Uspekhi gerontologii1 Jan 2013Cited by 1 (Europe PMC)

PMID28976148 (opens in a new tab)PepBankPUB-28976148
Publisher pageAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In young and old rats, Pinealon improved Morris labyrinth learning more than Cortexin.

    In plain wordsIn rats, Pinealon improved maze learning more than Cortexin.

    Peptide
    Pinealon
    Outcome
    IncreaseMorris labyrinth learning
    Study

    ratn: not reported in source

    Young and old rats
    Comparator
    Cortexin
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pinealon has prevalent positive effect on learning of both young and old animals in the Morris labyrinth compared to cortexin.
    1 context sentence
    Summary · context
    The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In young and old rats, Cortexin had a less favorable effect on Morris labyrinth learning than Pinealon.

    In plain wordsIn young and old rats, Cortexin had a less favorable effect on Morris labyrinth learning than Pinealon.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseMorris labyrinth learning
    Study

    ratn: not reported in source

    Young and old rats tested in the Morris labyrinth
    Comparator
    Pinealon
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pinealon has prevalent positive effect on learning of both young and old animals in the Morris labyrinth compared to cortexin.
    1 context sentence
    Summary · context
    The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held.

Studies that did not test the peptide alone3

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 03AnimalNot a test of Pinealon aloneAnimal study (in vivo)Mechanism

    In young and old rats, the study of Cortexin and Pinealon found regional changes in caspase-3 activity in cortex and brainstem.

    In plain wordsIn rats, the Cortexin and Pinealon study found regional changes in brain caspase activity without separate peptide estimates.

    Peptide
    Pinealon
    Outcome
    Direction not reportedRegional caspase-3 activity
    Study

    ratn: not reported in source

    Young and old rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Regional changes in activity and the content of caspase-3 in the cerebral cortex and brainstem of young and old rats under the influence of peptides were identified.
    1 context sentence
    Summary · context
    The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  2. 04AnimalNot a test of Pinealon aloneAnimal study (in vivo)Mechanism

    In young and old rats, the study of Cortexin and Pinealon found regional changes in caspase-3 content in cortex and brainstem.

    In plain wordsIn rats, the Cortexin and Pinealon study found regional changes in brain caspase content without separate peptide estimates.

    Peptide
    Pinealon
    Outcome
    Direction not reportedRegional caspase-3 content
    Study

    ratn: not reported in source

    Young and old rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Regional changes in activity and the content of caspase-3 in the cerebral cortex and brainstem of young and old rats under the influence of peptides were identified.
    1 context sentence
    Summary · context
    The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  3. 05AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Mechanism

    In young and old rats, peptide treatments including Cortexin changed regional caspase-3 activity and content in the cerebral cortex and brainstem.

    In plain wordsIn rats, peptide treatments including Cortexin changed caspase-3 activity and content in brain regions. The abstract does not state the direction.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedRegional caspase-3 activity and content
    Study

    ratn: not reported in source

    Young and old rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Regional changes in activity and the content of caspase-3 in the cerebral cortex and brainstem of young and old rats under the influence of peptides were identified.
    1 context sentence
    Summary · context
    The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.