Skip to content

Study · Animal study (in vivo) · mouse · 2017

4 results

Thymosin β4 attenuates liver fibrosis via suppressing Notch signaling.

Hong Y, Yao Q, Zheng L

Biochemical and biophysical research communications28 Sept 2017Cited by 14 (Europe PMC)

PMID28965947 (opens in a new tab)DOI10.1016/j.bbrc.2017.09.156 (opens in a new tab)PepBankPUB-28965947
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CCl4-induced liver fibrosis, Tβ4 attenuated hepatic fibrosis.

    In plain wordsIn mice with liver fibrosis, thymosin beta‑4 reduced liver scarring.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseHepatic fibrosis
    Study

    mousen: not reported in source

    CCl4-induced liver fibrosis
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study indicates that Tβ4 attenuates hepatic fibrosis and down-regulates the expression of fibrogenic genes in hepatic liver.
    1 context sentence
    Summary · context
    In the current study, we used CCl4-induced liver fibrosis model mice to investigate the effect of Tβ4 administration on fibrosis in vivo and the underlying mechanism.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CCl4-induced liver fibrosis, Tβ4 down-regulated the expression of fibrogenic genes in the liver.

    In plain wordsIn mice with liver fibrosis, thymosin beta‑4 lowered activity of genes that drive scarring in the liver.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseFibrogenic gene expression in liver
    Study

    mousen: not reported in source

    CCl4-induced liver fibrosis
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study indicates that Tβ4 attenuates hepatic fibrosis and down-regulates the expression of fibrogenic genes in hepatic liver.
    1 context sentence
    Summary · context
    In the current study, we used CCl4-induced liver fibrosis model mice to investigate the effect of Tβ4 administration on fibrosis in vivo and the underlying mechanism.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with CCl4-induced liver fibrosis, Tβ4 significantly reduced the expression of Notch2 and Notch3, which were increased in the liver.

    In plain wordsIn mice with liver fibrosis, thymosin beta‑4 reduced the raised levels of two Notch signalling proteins in the liver.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNotch2 and Notch3 expression in liver
    Study

    mousen: not reported in source

    CCl4-induced liver fibrosis
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further study revealed that Tβ4 attenuates liver fibrosis through inhibition of the Notch signaling, as Tβ4 significantly reduces the expression of Notch2 and Notch 3 that were increased in hepatic liver.
    1 context sentence
    Summary · context
    In the current study, we used CCl4-induced liver fibrosis model mice to investigate the effect of Tβ4 administration on fibrosis in vivo and the underlying mechanism.
  4. 04LabIn vitro (cells)Efficacy outcome

    In activated hepatic stellate cells, Tβ4 inhibited the expression of pro-fibrogenic and proliferation genes.

    In plain wordsIn lab cells, thymosin beta‑4 lowered activity of genes for scarring and growth in activated liver stellate cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePro-fibrogenic and proliferation gene expression in activated HSCs
    Study

    n: not reported in source

    Activated hepatic stellate cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Tβ4 inhibits the expression of pro fibrogenic and proliferation genes in activated HSCs.
    1 context sentence
    Summary · context
    In the current study, we used CCl4-induced liver fibrosis model mice to investigate the effect of Tβ4 administration on fibrosis in vivo and the underlying mechanism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.