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Study · In vitro (cells) · rat · 2018

8 results

Carnosine suppresses oxygen-glucose deprivation/recovery-induced proliferation and migration of reactive astrocytes of rats in vitro.

Ou-Yang L, Liu Y, Wang BY, Cao P, Zhang JJ, Huang YY, Shen Y, Lyu JX

Acta pharmacologica Sinica21 Sept 2017Cited by 27 (Europe PMC)

PMID28933425 (opens in a new tab)PMCIDPMC5758661 (opens in a new tab)DOI10.1038/aps.2017.126 (opens in a new tab)PepBankPUB-28933425
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In reactive rat astrocytes, carnosine pretreatment caused G1 arrest.

    In plain wordsIn rat cells, carnosine caused G1 arrest compared with oxygen-glucose deprivation/recovery without carnosine.

    Peptide
    L-carnosine
    Outcome
    IncreaseG1 arrest
    Study

    ratn: not reported in source

    primary cultured astrocytes exposed to oxygen-glucose deprivation/recovery
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mmol/LAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with carnosine (5 mmol/L) caused G1 arrest of reactive astrocytes, significantly attenuated OGD/R-induced increase in cyclin D1 protein expression and suppressed OGD/R-induced proliferation of reactive astrocytes.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.
  2. 02LabIn vitro (cells)Mechanism

    Carnosine significantly attenuated the oxygen-glucose deprivation/recovery-induced increase in cyclin D1 in rat astrocytes.

    In plain wordsIn cells from rats, carnosine reduced cyclin D1 compared with oxygen-glucose deprivation/recovery without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseCyclin D1 expression
    Study

    ratn: not reported in source

    primary cultured astrocytes exposed to oxygen-glucose deprivation/recovery
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mmol/LAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with carnosine (5 mmol/L) caused G1 arrest of reactive astrocytes, significantly attenuated OGD/R-induced increase in cyclin D1 protein expression and suppressed OGD/R-induced proliferation of reactive astrocytes.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.
  3. 03LabIn vitro (cells)Efficacy outcome

    Carnosine suppressed oxygen-glucose deprivation/recovery-induced proliferation of reactive rat astrocytes.

    In plain wordsIn cells from rats, carnosine reduced astrocyte proliferation compared with oxygen-glucose deprivation/recovery without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseReactive astrocyte proliferation
    Study

    ratn: not reported in source

    primary cultured astrocytes exposed to oxygen-glucose deprivation/recovery
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mmol/LAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with carnosine (5 mmol/L) caused G1 arrest of reactive astrocytes, significantly attenuated OGD/R-induced increase in cyclin D1 protein expression and suppressed OGD/R-induced proliferation of reactive astrocytes.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.
  4. 04LabIn vitro (cells)Mechanism

    Carnosine reversed elevated glycolysis after oxygen-glucose deprivation in rat astrocytes.

    In plain wordsIn rat cells, carnosine reduced elevated glycolysis compared with oxygen-glucose deprivation/recovery without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseGlycolysis
    Study

    ratn: not reported in source

    primary cultured astrocytes exposed to oxygen-glucose deprivation/recovery
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mmol/LAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment also reversed glycolysis and ATP production, which was elevated at 24 h recovery after OGD.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.
  5. 05LabIn vitro (cells)Mechanism

    Carnosine reversed elevated ATP production after oxygen-glucose deprivation in rat astrocytes.

    In plain wordsIn rat cells, carnosine reduced elevated ATP production compared with oxygen-glucose deprivation/recovery without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseATP production
    Study

    ratn: not reported in source

    primary cultured astrocytes exposed to oxygen-glucose deprivation/recovery
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mmol/LAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment also reversed glycolysis and ATP production, which was elevated at 24 h recovery after OGD.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.
  6. 06LabIn vitro (cells)Mechanism

    Carnosine reversed MMP-9 expression levels in reactive rat astrocytes after oxygen-glucose deprivation.

    In plain wordsIn rat cells, carnosine reversed MMP-9 expression changes compared with oxygen-glucose deprivation/recovery without carnosine.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedMMP-9 expression
    Study

    ratn: not reported in source

    primary cultured astrocytes exposed to oxygen-glucose deprivation/recovery
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mmol/LAs given in this study (rat).

    Source sentences

    Summary
    A marked increase in migration of reactive astrocytes was observed at 24 h after OGD, whereas carnosine treatment reversed the expression levels of MMP-9 and suppressed the migration of astrocytes.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.
  7. 07LabIn vitro (cells)Efficacy outcome

    Carnosine suppressed migration of reactive rat astrocytes after oxygen-glucose deprivation.

    In plain wordsIn cells from rats, carnosine reduced astrocyte migration compared with oxygen-glucose deprivation/recovery without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseAstrocyte migration
    Study

    ratn: not reported in source

    primary cultured astrocytes exposed to oxygen-glucose deprivation/recovery
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mmol/LAs given in this study (rat).

    Source sentences

    Summary
    A marked increase in migration of reactive astrocytes was observed at 24 h after OGD, whereas carnosine treatment reversed the expression levels of MMP-9 and suppressed the migration of astrocytes.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.
  8. 08LabIn vitro (cells)Efficacy outcome

    Carnosine improved neurite growth of cortical neurons co-cultured with astrocytes under ischemic conditions.

    In plain wordsIn cells, carnosine improved nerve projection growth under ischemic conditions compared with cultures without carnosine.

    Peptide
    L-carnosine
    Outcome
    IncreaseNeurite growth
    Study

    ratn: not reported in source

    cortical neurons co-cultured with astrocytes under ischemic conditions
    Comparator
    oxygen-glucose deprivation/recovery without carnosine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, carnosine also improved neurite growth of cortical neurons co-cultured with astrocytes under ischemic conditions.
    2 context sentences
    Summary · context
    In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro.
    Summary · context
    Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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