Kisspeptin regulates steroidogenesis and spermiation in anuran amphibian.

Chianese R, Ciaramella V, Fasano S, Pierantoni R, Meccariello R

Reproduction (Cambridge, England)1 Oct 2017Cited by 28 (Europe PMC)

PMID28878091DOI10.1530/rep-17-0030PepBankPUB-28878091

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In frogs, in vivo administration of kisspeptin‑10 did not induce sperm release in cloacal fluid.
In plain wordsIn frogs, kisspeptin‑10 given to the live animal did not cause sperm release.
Peptide
Kisspeptin-10
Outcome
No significant changeSperm release in cloacal fluid
Study
Pelophylax esculentusn: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
in vivo administration of Kp-10 has been unable to induce sperm release in cloacal fluid.
Report a problemFND-2887809107
02LabEx vivo tissueMechanism
In frog testis pieces ex vivo, kisspeptin‑10 treatment affected the expression of key steroidogenesis enzymes.
In plain wordsIn frog testis tissue in lab tests, kisspeptin‑10 changed the levels of key enzymes that make sex hormones.
Peptide
Kisspeptin-10
Outcome
Direction not reportedExpression of steroidogenic enzymes
Study
Pelophylax esculentusn: not reported in source
Testis pieces, ex vivo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10-9-10-6 MAs given in this study (Pelophylax esculentus).
Source sentences
Summary
Treatments have been carried out in February - when a new wave of spermatogenesis occurs - and affect the expression of key enzymes of steroidogenesis inducing opposite effects on testosterone and estradiol intratesticular levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Since the interstitium is the main site of localization of both ligand and receptor, its possible involvement in the regulation of steroidogenesis has been evaluated by ex vivo treatment of testis pieces with increasing doses of Kp-10 (10^-9-10^-6 M).
Report a problemFND-2887809103
03LabEx vivo tissueEfficacy outcome
In frog testis pieces ex vivo, kisspeptin‑10 had opposite effects on intratesticular testosterone and estradiol levels.
In plain wordsIn frog testis tissue in lab tests, kisspeptin‑10 moved testosterone and estradiol levels in opposite directions.
Peptide
Kisspeptin-10
Outcome
MixedIntratesticular testosterone and estradiol levels
Study
Pelophylax esculentusn: not reported in source
Testis pieces, ex vivo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10-9-10-6 MAs given in this study (Pelophylax esculentus).
Source sentences
Summary
Treatments have been carried out in February - when a new wave of spermatogenesis occurs - and affect the expression of key enzymes of steroidogenesis inducing opposite effects on testosterone and estradiol intratesticular levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Since the interstitium is the main site of localization of both ligand and receptor, its possible involvement in the regulation of steroidogenesis has been evaluated by ex vivo treatment of testis pieces with increasing doses of Kp-10 (10^-9-10^-6 M).
Report a problemFND-2887809104
04LabEx vivo tissueEfficacy outcome
In frog testis pieces ex vivo, kisspeptin treatment increased the number of tubules with spermatozoa detached from Sertoli cells versus control.
In plain wordsIn frog testis tissue in lab tests, kisspeptin led to more tubules with sperm detached from supporting cells than control.
Peptide
Kisspeptin-10
Outcome
IncreaseTubules with spermatozoa detached from Sertoli cells
Study
Pelophylax esculentusn: not reported in source
Testis pieces, ex vivo
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10-9-10-6 MAs given in this study (Pelophylax esculentus).
Source sentences
Summary
Morphological analysis of Kp-treated testes reveals higher number of tubules with spermatozoa detached from Sertoli cells than control group
1 context sentence(design, population, supporting numbers)
Summary · context
Since the interstitium is the main site of localization of both ligand and receptor, its possible involvement in the regulation of steroidogenesis has been evaluated by ex vivo treatment of testis pieces with increasing doses of Kp-10 (10^-9-10^-6 M).
Report a problemFND-2887809105
05LabEx vivo tissueMechanism
In frog testis pieces ex vivo, kisspeptin treatment strongly affected expression of connexin 43, the main junctional protein of the testis.
In plain wordsIn frog testis tissue in lab tests, kisspeptin strongly changed levels of connexin 43, a protein that links testis cells.
Peptide
Kisspeptin-10
Outcome
Direction not reportedConnexin 43 expression
Study
Pelophylax esculentusn: not reported in source
Testis pieces, ex vivo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10-9-10-6 MAs given in this study (Pelophylax esculentus).
Source sentences
Summary
the expression of connexin 43, the main junctional protein in testis, is deeply affected by the treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Since the interstitium is the main site of localization of both ligand and receptor, its possible involvement in the regulation of steroidogenesis has been evaluated by ex vivo treatment of testis pieces with increasing doses of Kp-10 (10^-9-10^-6 M).
Report a problemFND-2887809106

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06LabEndogenous levelEx vivo tissueOther
In the testis of the frog Pelophylax esculentus, the body's own Kiss-1 and Gpr54 proteins were expressed during the annual sexual cycle.
In plain wordsIn frogs, testes make the body's own kisspeptin system proteins during the yearly sexual cycle.
Peptide
Kisspeptin-10
Outcome
Not applicableTestis Kiss-1 and Gpr54 protein expression
Study
Pelophylax esculentusn: not reported in source
Testis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
testis expresses both Kiss-1 and Gpr54 proteins during the annual sexual cycle
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2887809101
07LabEndogenous levelEx vivo tissueMechanism
In frog testis ex vivo, 17B-estradiol increased expression of the body's own Kiss-1 and Gpr54 proteins over control.
In plain wordsIn frog testis tissue, estradiol raised the body's own kisspeptin system proteins compared with control.
Peptide
Kisspeptin-10
Outcome
IncreaseTestis Kiss-1 and Gpr54 protein expression after estradiol
Study
Pelophylax esculentusn: not reported in source
Testis, ex vivo
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
ex vivo 17B-estradiol (E₂, 10^-6 M) increases both proteins over control group.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2887809102

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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