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Study · Animal study (in vivo) · pig · 2018

8 results

Design and biological effects of a vaginally administered gel containing the GnRH agonist, triptorelin, for synchronizing ovulation in swine.

Knox RV, Stewart KR, Flowers WL, Swanson ME, Webel SK, Kraeling RR

Theriogenology24 Aug 2017Cited by 18 (Europe PMC)

PMID28863964 (opens in a new tab)DOI10.1016/j.theriogenology.2017.08.021 (opens in a new tab)PepBankPUB-28863964
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In gilts, 100 μg triptorelin was the lowest dose that induced an LH surge in the most animals.

    In plain wordsIn pigs, 100 μg triptorelin was the lowest dose that induced an LH surge in the most gilts.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseLH surge in gilts
    Study

    pign: not reported in source

    gilts and weaned sows
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 μg in 1.2% methylcellulose gel · intravaginalAs given in this study (pig).

    Source sentences

    Summary
    The lowest dose of triptorelin that induced the most gilts to show an LH surge was 100 μg in 1.2% methylcellulose gel.
    1 context sentence
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In weaned sows, triptorelin gel produced an LH response similar to that in gilts.

    In plain wordsIn pigs, triptorelin gel produced a similar LH response in weaned sows and gilts.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeLH response in weaned sows
    Study

    pign: not reported in source

    gilts and weaned sows
    Comparator
    Gilts receiving the same formulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 μg in 1.2% methylcellulose gel · intravaginalAs given in this study (pig).

    Source sentences

    Summary
    This formulation had a similar effect in weaned sows while also advancing ovulation.
    2 context sentences
    Summary · context
    The lowest dose of triptorelin that induced the most gilts to show an LH surge was 100 μg in 1.2% methylcellulose gel.
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In weaned sows, triptorelin gel advanced ovulation.

    In plain wordsIn pigs, triptorelin gel advanced ovulation in weaned sows.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseOvulation timing in weaned sows
    Study

    pign: not reported in source

    gilts and weaned sows
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 μg in 1.2% methylcellulose gel · intravaginalAs given in this study (pig).

    Source sentences

    Summary
    This formulation had a similar effect in weaned sows while also advancing ovulation.
    2 context sentences
    Summary · context
    The lowest dose of triptorelin that induced the most gilts to show an LH surge was 100 μg in 1.2% methylcellulose gel.
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In weaned sows, triptorelin at 96 h induced ovulation by 48 h in 58% versus 34% of controls.

    In plain wordsIn pigs, triptorelin after weaning increased ovulation within 48 h compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseOvulation within 48 hours versus control
    Study

    pign: not reported in source

    gilts and weaned sows
    Comparator
    Control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravaginalAs given in this study (pig).

    Source sentences

    Summary
    Administration at 96 h induced more sows to ovulate (58%) by 48 h compared to treatment at estrus (45%) or for controls (34%), but the desired level of ovulation synchrony was not achieved.
    1 context sentence
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In weaned sows, the initial triptorelin regimen did not achieve the desired ovulation synchrony.

    In plain wordsIn pigs, the initial triptorelin regimen did not achieve the desired ovulation synchrony.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Direction not reportedOvulation synchrony with initial regimen
    Study

    pign: not reported in source

    gilts and weaned sows
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravaginalAs given in this study (pig).

    Source sentences

    Summary
    Administration at 96 h induced more sows to ovulate (58%) by 48 h compared to treatment at estrus (45%) or for controls (34%), but the desired level of ovulation synchrony was not achieved.
    1 context sentence
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In weaned sows, 200 μg triptorelin induced ovulation within 48 h in 81% of animals.

    In plain wordsIn pigs, 200 μg triptorelin induced ovulation within 48 h in 81% of weaned sows.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableOvulation within 48 hours at higher dose
    Study

    pign: not reported in source

    gilts and weaned sows
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 μg at 96 h after weaning · intravaginalAs given in this study (pig).

    Measurements

    Ovulation rate
    81%
    200 μg at 96 h after weaning

    Source sentences

    Summary
    As a result, greater doses of triptorelin were tested and 200 μg given at 96 h after weaning, induced 81% of sows to ovulate within 48 h after treatment.
    1 context sentence
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.

Studies that did not test the peptide alone2

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 07AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome

    In weaned sows, triptorelin gel followed by fixed-time insemination increased farrowing rates to 82.5% versus 80.1% in controls.

    In plain wordsIn pigs, triptorelin gel followed by fixed-time insemination increased farrowing rates compared with control weaned sows.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseFarrowing rate
    Study

    pign: not reported in source

    gilts and weaned sows
    Comparator
    Control weaned sows
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In field trials, a SFT-AI 22 ± 2 h after all weaned sows were treated with OvuGel improved (P = 0.04) farrowing rate to 82.5% compared to control sows weaned (80.1%), with no effect on numbers of pigs born alive (12.1).
    2 context sentences
    Summary · context
    The optimum time to give a single fixed time AI (SFT-AI) after administration of 200 μg of triptorelin in 1.2% gel (OvuGel®) at 96 h after weaning was tested.
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 08AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome

    In weaned sows, triptorelin gel followed by fixed-time insemination did not affect numbers of pigs born alive.

    In plain wordsIn pigs, triptorelin gel followed by fixed-time insemination did not change the number born alive compared with control weaned sows.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePigs born alive
    Study

    pign: not reported in source

    gilts and weaned sows
    Comparator
    Control weaned sows
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In field trials, a SFT-AI 22 ± 2 h after all weaned sows were treated with OvuGel improved (P = 0.04) farrowing rate to 82.5% compared to control sows weaned (80.1%), with no effect on numbers of pigs born alive (12.1).
    2 context sentences
    Summary · context
    The optimum time to give a single fixed time AI (SFT-AI) after administration of 200 μg of triptorelin in 1.2% gel (OvuGel®) at 96 h after weaning was tested.
    Summary · context
    A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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