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Study · In vitro (cells) · mouse · 2017

11 results

Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.

Mijiddorj T, Kanasaki H, Oride A, Hara T, Sukhbaatar U, Tumurbaatar T, Kyo S

Biology of reproduction1 May 2017Cited by 9 (Europe PMC)

PMID28863434 (opens in a new tab)DOI10.1093/biolre/iox030 (opens in a new tab)PepBankPUB-28863434
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells overexpressing Kiss1r, kisspeptin‑10 significantly increased promoter activities of the Cga, Lhb and Fshb gonadotropin subunits.

    In plain wordsIn mouse pituitary cells, kisspeptin‑10 raised the activity of the genes for three gonadotropin parts.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGonadotropin subunit promoter activities (Cga, Lhb, Fshb)
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin-10 (KP10) significantly increased the promoter activities of the gonadotropin subunits, common alpha-glycoprotein (Cga), luteinizing hormone beta (Lhb), and follicle-stimulatinghormone beta (Fshb) in LbetaT2 cells overexpressing kisspeptin receptor (Kiss1r).
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.
  2. 02LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, kisspeptin‑10 and GnRH increased gonadotropin subunit levels to similar degrees.

    In plain wordsIn mouse pituitary cells, kisspeptin‑10 and GnRH raised gonadotropin subunit levels by similar amounts.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGonadotropin subunit levels, KP10 versus GnRH
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Comparator
    GnRH
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP10 and gonadotropin-releasing hormone (GnRH) increased gonadotropin subunit levels to similar degrees
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.
  3. 03LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, combined treatment with GnRH and kisspeptin‑10 did not potentiate their individual effects on gonadotropin subunit levels.

    In plain wordsIn mouse pituitary cells, giving GnRH and kisspeptin‑10 together did not raise gonadotropin subunits more than each alone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGonadotropin subunit levels, KP10 plus GnRH
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Comparator
    Individual effects of KP10 and GnRH
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    combined treatment with GnRH and KP10 did not potentiate their individual effects.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.
  4. 04LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, stimulation with both kisspeptin‑10 and ADCYAP1 increased gonadotropin subunit expression further than either alone.

    In plain wordsIn mouse pituitary cells, kisspeptin‑10 with ADCYAP1 raised gonadotropin subunit expression more than either one alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGonadotropin subunit expression, KP10 plus ADCYAP1
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Comparator
    KP10 alone; ADCYAP1 alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When cells were stimulated with both KP10 and ADCYAP1, expression of gonadotropin subunits was further increased compared to KP10 or ADCYAP1 alone.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.
  5. 05LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, kisspeptin‑10 dramatically increased serum response element (Sre) promoter levels.

    In plain wordsIn mouse pituitary cells, kisspeptin‑10 strongly raised the activity of one signalling-response gene switch (Sre).

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSre promoter level
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP10 and GnRH dramatically increased serum response element (Sre) promoter levels but only slightly increased cAMP response element (Cre) promoter levels.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.
  6. 06LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, kisspeptin‑10 only slightly increased cAMP response element (Cre) promoter levels.

    In plain wordsIn mouse pituitary cells, kisspeptin‑10 raised the activity of a second gene switch (Cre) only slightly.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCre promoter level
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP10 and GnRH dramatically increased serum response element (Sre) promoter levels but only slightly increased cAMP response element (Cre) promoter levels.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.
  7. 07LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, stimulation with both kisspeptin‑10 and GnRH further increased Sre promoter levels.

    In plain wordsIn mouse pituitary cells, adding GnRH to kisspeptin‑10 raised Sre gene-switch activity further.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSre promoter level, KP10 plus GnRH
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Combined stimulation with KP10 and GnRH further increased Sre promoter levels.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.
  8. 08LabIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, kisspeptin‑10 increased expression of the ADCYAP1 type I receptor (Adcyap1r).

    In plain wordsIn mouse pituitary cells, kisspeptin‑10 raised the amount of the ADCYAP1 receptor.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseAdcyap1r expression
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also found that KP10 increases Adcyap1r expression.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 09LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, ADCYAP1 did not modify the effect of kisspeptin‑10 on Sre promoter expression.

    In plain wordsIn mouse pituitary cells, ADCYAP1 did not change how much kisspeptin‑10 raised Sre gene-switch activity.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeSre promoter level, KP10 plus ADCYAP1
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Comparator
    KP10 alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In contrast, ADCYAP1 slightly increased Sre promoter expression but did not modify the effect of KP10.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 10LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, combined treatment with kisspeptin‑10 and ADCYAP1 further increased Cre promoter expression compared with kisspeptin‑10 alone.

    In plain wordsIn mouse pituitary cells, kisspeptin‑10 with ADCYAP1 raised Cre gene-switch activity more than kisspeptin‑10 alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCre promoter level, KP10 plus ADCYAP1
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Comparator
    KP10 alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    However, ADCYAP1 increased Cre promoter to greater levels than KP10 alone, and combined treatment with KP10 and ADCYAP1 further increased Cre promoter expression.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 11LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In mouse LbetaT2 cells, a higher amount of Adcyap1r vector did not alter the kisspeptin‑10-induced fold increase in the three gonadotropin subunit promoters.

    In plain wordsIn mouse pituitary cells, more ADCYAP1 receptor did not change how much kisspeptin‑10 raised the three gonadotropin gene switches.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKP10-induced fold increase in gonadotropin subunit promoters with higher Adcyap1r
    Study

    mousen: not reported in source

    Mouse pituitary LbetaT2 cells
    Comparator
    Lower Adcyap1r transfection
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The KP10-induced fold increase in all three gonadotropin subunit promoters was not altered by transfection with a higher amount of Adcyap1r vector.
    1 context sentence
    Title · context
    Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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