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Study · Animal study (in vivo) · rat · 2017

9 results

Mechanistic Evaluation of the Protective Effect of Carnosine on Acute Lung Injury in Sepsis Rats.

Sun C, Wu Q, Zhang X, He Q, Zhao H

Pharmacology25 Aug 2017Cited by 26 (Europe PMC)

PMID28848223 (opens in a new tab)DOI10.1159/000479879 (opens in a new tab)PepBankPUB-28848223
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine significantly renormalized lipid peroxidation.

    In plain wordsIn rats with sepsis, carnosine returned lipid oxidation toward normal.

    Peptide
    L-carnosine
    Outcome
    MixedLipid peroxidation
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment significantly renormalized the lipid peroxidation and other antioxidant enzymes.
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine significantly renormalized antioxidant enzymes.

    In plain wordsIn rats with sepsis, carnosine returned antioxidant enzymes toward normal.

    Peptide
    L-carnosine
    Outcome
    MixedAntioxidant enzymes
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment significantly renormalized the lipid peroxidation and other antioxidant enzymes.
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine reduced IL-β.

    In plain wordsIn rats with sepsis, carnosine reduced IL-beta.

    Peptide
    L-carnosine
    Outcome
    DecreaseIL-beta
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    IL-β, TNF-α, and MIF were found to be reduced after carnosine treatment.
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine reduced TNF-α.

    In plain wordsIn rats with sepsis, carnosine reduced TNF-alpha.

    Peptide
    L-carnosine
    Outcome
    DecreaseTNF-alpha
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    IL-β, TNF-α, and MIF were found to be reduced after carnosine treatment.
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine reduced MIF.

    In plain wordsIn rats with sepsis, carnosine reduced MIF.

    Peptide
    L-carnosine
    Outcome
    DecreaseMIF
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    IL-β, TNF-α, and MIF were found to be reduced after carnosine treatment.
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In septic rats, carnosine significantly reduced sepsis intensity on histopathological analysis.

    In plain wordsIn rats with sepsis, carnosine reduced disease intensity in tissue examinations.

    Peptide
    L-carnosine
    Outcome
    DecreaseHistopathological sepsis intensity
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    After carnosine treatment, the intensity of sepsis was significantly reduced evidenced by histopathological analysis.
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine increased IκBα expression.

    In plain wordsIn rats with sepsis, carnosine increased IκBα expression.

    Peptide
    L-carnosine
    Outcome
    IncreaseIκBα expression
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    In western blot analysis, carnosine treatment causes the upregulation of IκBα together with the downregulation of the expressions of p65 and p-IKKα/β (Ser 180/Ser 181).
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine decreased p65 expression.

    In plain wordsIn rats with sepsis, carnosine decreased p65 expression.

    Peptide
    L-carnosine
    Outcome
    Decreasep65 expression
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    In western blot analysis, carnosine treatment causes the upregulation of IκBα together with the downregulation of the expressions of p65 and p-IKKα/β (Ser 180/Ser 181).
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In septic rats, carnosine decreased p-IKKα/β expression.

    In plain wordsIn rats with sepsis, carnosine decreased p-IKKα/β expression.

    Peptide
    L-carnosine
    Outcome
    Decreasep-IKKα/β expression
    Study

    ratn: not reported in source

    Experimentally induced sepsis in male albino rats
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    25 mg/kg and 50 mg/kg · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    In western blot analysis, carnosine treatment causes the upregulation of IκBα together with the downregulation of the expressions of p65 and p-IKKα/β (Ser 180/Ser 181).
    2 context sentences
    Summary · context
    This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats.
    Summary · context
    Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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