Skip to content

Study · In vitro (cells) · bovine · 2017

9 results

Effect of kisspeptin on the proliferation and apoptosis of bovine granulosa cells.

Liu H, Xu G, Yuan Z, Dong Y, Wang J, Lu W

Animal reproduction science20 Jul 2017Cited by 17 (Europe PMC)

PMID28830628 (opens in a new tab)DOI10.1016/j.anireprosci.2017.07.008 (opens in a new tab)PepBankPUB-28830628
Publisher pagePubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In bovine granulosa cells, 100 nM Kp-10 significantly inhibited cell viability.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 reduced cell survival.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseGranulosa cell viability
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    100 nMAs given in this study (bovine).

    Source sentences

    Summary
    Moreover, MTT assays showed that 100nM Kp-10 significantly inhibited the viability of granulosa cells (P<0.05).
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In bovine granulosa cells, Kp-10 significantly increased accumulation of cells in the G1 phase.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 made more cells stay in the G1 phase.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseG1 phase cell accumulation
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometry analysis showed that Kp-10 could significantly increase accumulation of cells in the G1 phase
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In bovine granulosa cells, Kp-10 significantly decreased accumulation of cells in the S phase.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 left fewer cells in the S phase.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseS phase cell accumulation
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decrease accumulation of cells in the S phase
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.
  4. 04LabIn vitro (cells)Efficacy outcome

    In bovine granulosa cells, Kp-10 promoted apoptosis.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 increased cell death.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseApoptosis
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    promote apoptosis in bovine granulosa cells (P<0.05).
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.
  5. 05LabIn vitro (cells)Mechanism

    In bovine granulosa cells, Kp-10 decreased mRNA levels of the anti-apoptotic gene Bcl-2.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 lowered the activity of a gene that blocks cell death.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseBcl-2 mRNA level
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, Kp-10 decreased the mRNA levels of Bcl-2, an anti-apoptotic gene
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.
  6. 06LabIn vitro (cells)Mechanism

    In bovine granulosa cells, Kp-10 increased mRNA levels of the pro-apoptotic gene caspase-3.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 raised the activity of a gene that drives cell death.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCaspase-3 mRNA level
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased the mRNA levels of caspase-3, a pro-apoptotic gene; and increased the mRNA levels of Fas and Fasl (P< 0.05).
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.
  7. 07LabIn vitro (cells)Mechanism

    In bovine granulosa cells, Kp-10 increased Fas mRNA levels.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 raised activity of the Fas gene.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFas mRNA level
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased the mRNA levels of Fas and Fasl (P< 0.05).
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.
  8. 08LabIn vitro (cells)Mechanism

    In bovine granulosa cells, Kp-10 increased Fasl mRNA levels.

    In plain wordsIn bovine ovary cells in the lab, Kp-10 raised activity of the Fasl gene.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFasl mRNA level
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased the mRNA levels of Fas and Fasl (P< 0.05).
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 09LabEndogenous levelIn vitro (cells)Mechanism

    In bovine ovarian granulosa cells, Kp-10 was expressed in the cytoplasm.

    In plain wordsIn bovine ovary cells, natural Kp-10 was present in the cell cytoplasm.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKp-10 expression in granulosa cells
    Study

    bovinen: not reported in source

    bovine ovarian granulosa cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Immunohistochemical analysis showed that Kp-10 was expressed in the cytoplasm of bovine ovarian granulosa cells.
    1 context sentence
    Summary · context
    In this study, we assessed the expression of Kp-10 and its effects on the proliferation and apoptosis of bovine granulosa cells.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.