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Study · Not a test of the peptide alone · 2017

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Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates.

Logan IS

Zoological research1 Jul 2017Cited by 14 (Europe PMC)

PMID28825450 (opens in a new tab)PMCIDPMC5571476 (opens in a new tab)DOI10.24272/j.issn.2095-8137.2017.049 (opens in a new tab)PepBankPUB-28825450
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Summary

In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human Humanin sequences in the GenBank database are unaffected by mutations. However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others. The persistence, or loss, of a functional Humanin gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer's disease (AD). The exact reason why Humanin underwent pseudogenization in some vertebrate species during their evolution remains to be determined. This study was originally planned to review the available information about Humanin and it was a surprise to be able to show that pseudogenization has occurred in a gene in the mtDNA and is not restricted solely to chromosomal genes.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01Computer modelNot a test of Humanin aloneIn silicoOther

    In GenBank data mining, 99.4% of human Humanin sequences were unaffected by mutations.

    In plain wordsIn a computer search of gene records, 99.4% of human Humanin gene sequences had no mutations.

    Peptide
    Humanin
    Outcome
    Not applicableMutations in human Humanin gene sequences
    Study

    humann: not reported in source

    GenBank sequence data mining
    Outcome group
    Aging markers · Whole body

    Measurements

    Unaffected human Humanin sequences
    99.4%
    GenBank database

    Source sentences

    Summary
    By using simple data mining techniques, it is possible to show that 99.4% of the human Humanin sequences in the GenBank database are unaffected by mutations.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02Computer modelNot a test of Humanin aloneIn silicoOther

    In other vertebrates, pseudogenization of the Humanin gene is common, occurring apparently randomly in some species and not others.

    In plain wordsIn a computer search, the Humanin gene had lost its function in some vertebrate species but not in others.

    Peptide
    Humanin
    Outcome
    Not applicablePseudogenization of the Humanin gene in other vertebrates
    Study

    vertebratesn: not reported in source

    GenBank sequence data mining
    Outcome group
    Aging markers · Whole body

    Source sentences

    Summary
    However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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