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Study · Animal study (in vivo) · mouse · 2017

15 results

NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia.

Wei CC, Kong YY, Hua X, Li GQ, Zheng SL, Cheng MH, Wang P, Miao CY

British journal of pharmacology6 Sept 2017Cited by 73 (Europe PMC)

PMID28812311 (opens in a new tab)PMCIDPMC5647191 (opens in a new tab)DOI10.1111/bph.13979 (opens in a new tab)PepBankPUB-28812311
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In mice with cerebral ischemia, NMN significantly prevented the mortality increase induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN reduced the mortality increase from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMortality
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Mortality · Whole body
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    All these tPA-induced alterations were significantly prevented by NMN administration.
    3 context sentences
    Summary · context
    In the mice infused with tPA at 5 h post ischaemia, there were significant increases in mortality, brain infarction, brain oedema, brain haemoglobin level, neural apoptosis, Iba-1 staining (microglia activation) and myeloperoxidase staining (neutrophil infiltration).
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cerebral ischemia, NMN significantly prevented the brain infarction increase induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN reduced infarction caused by delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBrain infarction
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    All these tPA-induced alterations were significantly prevented by NMN administration.
    3 context sentences
    Summary · context
    In the mice infused with tPA at 5 h post ischaemia, there were significant increases in mortality, brain infarction, brain oedema, brain haemoglobin level, neural apoptosis, Iba-1 staining (microglia activation) and myeloperoxidase staining (neutrophil infiltration).
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cerebral ischemia, NMN significantly prevented the brain edema increase induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN reduced swelling from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBrain edema
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    All these tPA-induced alterations were significantly prevented by NMN administration.
    3 context sentences
    Summary · context
    In the mice infused with tPA at 5 h post ischaemia, there were significant increases in mortality, brain infarction, brain oedema, brain haemoglobin level, neural apoptosis, Iba-1 staining (microglia activation) and myeloperoxidase staining (neutrophil infiltration).
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cerebral ischemia, NMN significantly prevented the brain hemoglobin increase induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN reduced brain hemoglobin increases from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBrain hemoglobin level
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    All these tPA-induced alterations were significantly prevented by NMN administration.
    3 context sentences
    Summary · context
    In the mice infused with tPA at 5 h post ischaemia, there were significant increases in mortality, brain infarction, brain oedema, brain haemoglobin level, neural apoptosis, Iba-1 staining (microglia activation) and myeloperoxidase staining (neutrophil infiltration).
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN significantly prevented the neural apoptosis increase induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN reduced neural apoptosis from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseNeural apoptosis
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    All these tPA-induced alterations were significantly prevented by NMN administration.
    3 context sentences
    Summary · context
    In the mice infused with tPA at 5 h post ischaemia, there were significant increases in mortality, brain infarction, brain oedema, brain haemoglobin level, neural apoptosis, Iba-1 staining (microglia activation) and myeloperoxidase staining (neutrophil infiltration).
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN significantly prevented increased Iba-1 staining induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN reduced microglia activation from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseIba-1 staining
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    All these tPA-induced alterations were significantly prevented by NMN administration.
    3 context sentences
    Summary · context
    In the mice infused with tPA at 5 h post ischaemia, there were significant increases in mortality, brain infarction, brain oedema, brain haemoglobin level, neural apoptosis, Iba-1 staining (microglia activation) and myeloperoxidase staining (neutrophil infiltration).
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN significantly prevented increased myeloperoxidase staining induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN reduced neutrophil infiltration from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMyeloperoxidase staining
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    All these tPA-induced alterations were significantly prevented by NMN administration.
    3 context sentences
    Summary · context
    In the mice infused with tPA at 5 h post ischaemia, there were significant increases in mortality, brain infarction, brain oedema, brain haemoglobin level, neural apoptosis, Iba-1 staining (microglia activation) and myeloperoxidase staining (neutrophil infiltration).
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked the BBB permeability increase induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly reduced barrier permeability changes from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBBB permeability
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked claudin-1 downregulation induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly prevented claudin-1 loss from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseClaudin-1 expression
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked occludin downregulation induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly prevented occludin loss from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOccludin expression
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked zonula occludens-1 downregulation induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly prevented zonula occludens-1 loss from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseZonula occludens-1 expression
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked increased MMP9 activity induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly reduced MMP9 activity increases from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMMP9 activity
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked increased MMP2 activity induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly reduced MMP2 activity increases from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMMP2 activity
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  14. 14AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked increased MMP9 protein expression induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly reduced MMP9 protein increases from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMMP9 protein expression
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).
  15. 15AnimalAnimal study (in vivo)Mechanism

    In mice with cerebral ischemia, NMN partly blocked increased MMP2 protein expression induced by delayed tPA.

    In plain wordsIn mice with brain ischemia, NMN partly reduced MMP2 protein increases from delayed tPA compared with tPA without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMMP2 protein expression
    Study

    mousen: not reported in source

    CD1 mice with middle cerebral artery occlusion and delayed tPA
    Comparator
    delayed tPA without NMN
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    300 mg·kg-1 · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, NMN administration partly blocked these tPA-induced molecular changes.
    3 context sentences
    Summary · context
    Mechanistically, the delayed tPA treatment increased BBB permeability by down-regulating TJPs, including claudin-1, occludin and zonula occludens-1, and enhancing the activities and protein expression of MMP9 and MMP2.
    Summary · context
    Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.
    Summary · context
    A single dose of NMN was injected i.p. (300 mg·kg-1 ).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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