Skip to content

Study · In vitro (cells) · bacteria · 2017

5 results

Thymosin β4 is involved in the antimicrobial immune response of Golden pompano, Trachinotus ovatus.

Sun Y, Chen X, Xu Y, Liu Q, Jiang X, Wang S, Guo W, Zhou Y

Fish & shellfish immunology10 Aug 2017Cited by 18 (Europe PMC)

PMID28803959 (opens in a new tab)DOI10.1016/j.fsi.2017.08.006 (opens in a new tab)PepBankPUB-28803959
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    Purified recombinant TroTβ4 inhibited bacterial growth in vitro.

    In plain wordsIn lab tests, purified fish thymosin beta‑4 slowed the growth of bacteria.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseBacterial growth inhibition by recombinant TroTβ4
    Study

    bacterian: not reported in source

    Bacterial growth curve analyzer
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Purified recombinant TroTβ4 (rTroTβ4) inhibited the growth of bacteria
    1 context sentence
    Summary · context
    In the current study, we cloned and identified thymosin beta 4 from the teleost fish Golden pompano (Trachinotus ovatus), which we have named TroTβ4.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In Golden pompano, TroTβ4 expression was most abundant in immune organs.

    In plain wordsIn Golden pompano fish, the body's own thymosin beta‑4 was most abundant in immune organs.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTroTβ4 expression across tissues
    Study

    Trachinotus ovatusn: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The expression of TroTβ4 was most abundant in immune organs, and was significantly up-regulated in response to infection bacterial with one of a number of bacteria (including Edwardsiella tarda, Vibrio harveyi, and Streptococcus agalactiae).
    1 context sentence
    Summary · context
    In the current study, we cloned and identified thymosin beta 4 from the teleost fish Golden pompano (Trachinotus ovatus), which we have named TroTβ4.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In Golden pompano, TroTβ4 expression was significantly up-regulated after infection with bacteria including Edwardsiella tarda, Vibrio harveyi and Streptococcus agalactiae.

    In plain wordsIn Golden pompano fish, the body's own thymosin beta‑4 rose after bacterial infection.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTroTβ4 expression after bacterial infection
    Study

    Trachinotus ovatusn: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    significantly up-regulated in response to infection bacterial with one of a number of bacteria (including Edwardsiella tarda, Vibrio harveyi, and Streptococcus agalactiae).
    1 context sentence
    Summary · context
    In the current study, we cloned and identified thymosin beta 4 from the teleost fish Golden pompano (Trachinotus ovatus), which we have named TroTβ4.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In Golden pompano, in vivo overexpression of TroTβ4 significantly reduced bacterial colonization of tissues.

    In plain wordsIn Golden pompano fish, raising Tβ4 gene activity strongly reduced bacteria in tissues.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseBacterial colonization after TroTβ4 overexpression
    Study

    Trachinotus ovatusn: not reported in source

    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    When administered in vivo, overexpression of TroTβ4 in T. ovatus, bacterial colonization of tissues was significantly reduced.
    1 context sentence
    Summary · context
    In the current study, we cloned and identified thymosin beta 4 from the teleost fish Golden pompano (Trachinotus ovatus), which we have named TroTβ4.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In Golden pompano, siRNA knockdown of TroTβ4 expression significantly increased bacterial dissemination and colonization of tissues.

    In plain wordsIn Golden pompano fish, lowering the body's own thymosin beta‑4 increased bacterial spread in tissues.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseBacterial dissemination and colonization after TroTβ4 knockdown
    Study

    Trachinotus ovatusn: not reported in source

    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    In contrast, when a DNA vector-based siRNA technology was used to knock down TroTβ4 expression, bacterial dissemination and colonization of tissues increased significantly.
    1 context sentence
    Summary · context
    In the current study, we cloned and identified thymosin beta 4 from the teleost fish Golden pompano (Trachinotus ovatus), which we have named TroTβ4.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.