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Study · Ex vivo tissue · 2018

2 results

Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.

Thummasorn S, Shinlapawittayatorn K, Khamseekaew J, Jaiwongkam T, Chattipakorn SC, Chattipakorn N

Mitochondrion9 Aug 2017Cited by 45 (Europe PMC)

PMID28802666 (opens in a new tab)DOI10.1016/j.mito.2017.08.001 (opens in a new tab)PepBankPUB-28802666
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In isolated cardiac mitochondria, HNG had direct protective effects on mitochondrial function against hydrogen peroxide-induced oxidative stress.

    In plain wordsIn lab tests on isolated heart mitochondria, HNG directly protected mitochondrial function against oxidative stress.

    Peptide
    Humanin
    Outcome
    IncreaseCardiac mitochondrial function under H2O2-induced oxidative stress
    Study

    n: not reported in source

    Isolated cardiac mitochondria under H2O2-induced oxidative stress
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that HNG has direct protective effects on cardiac mitochondrial function against H2O2 induced oxidative stress through decreasing complex I activity.
    1 context sentence
    Summary · context
    Thus, we sought to determine the effects of HNG on mitochondrial function under hydrogen peroxide (H2O2) induced oxidative stress in isolated cardiac mitochondria.
  2. 02LabEx vivo tissueMechanism

    In isolated cardiac mitochondria, HNG protected function against oxidative stress through decreasing complex I activity.

    In plain wordsIn lab tests on isolated heart mitochondria, HNG lowered complex I activity, which was linked to its protection.

    Peptide
    Humanin
    Outcome
    DecreaseComplex I activity
    Study

    n: not reported in source

    Isolated cardiac mitochondria under H2O2-induced oxidative stress
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that HNG has direct protective effects on cardiac mitochondrial function against H2O2 induced oxidative stress through decreasing complex I activity.
    1 context sentence
    Summary · context
    Thus, we sought to determine the effects of HNG on mitochondrial function under hydrogen peroxide (H2O2) induced oxidative stress in isolated cardiac mitochondria.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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