Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats.

Hou Y, Wang X, Ping J, Lei Z, Gao Y, Ma Z, Jia C, Zhang Z, Li X, Jin M, Li X, Suo C, Zhang Y, Su J

Scientific reports1 Aug 2017Cited by 23 (Europe PMC)

PMID28765538PMCIDPMC5539146DOI10.1038/s41598-017-06017-1PepBankPUB-28765538

Summary

The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistical analyses. At the end point of the heat stress experiment, histological observation, ultrastructural analysis and biochemical parameters were measured. Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways. Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels. These results provide important mechanistic insights into the protective effects of Kisspeptin against heat-induced oxidative stress.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with heat-stress liver injury, kisspeptin mainly attenuated the alteration of the purine metabolism pathway in liver tissue.
In plain wordsIn heat-stressed rats, kisspeptin reduced heat-caused changes in a liver metabolic pathway called purine metabolism.
Peptide
Kisspeptin-10
Outcome
DecreasePurine metabolism alteration in liver
Study
ratn: not reported in source
Heat-stress liver injury
Outcome group
Metabolic pathways and metabolomics · Liver
Studied dose
Dose not stated
Source sentences
Summary
Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways.
1 context sentence(design, population, supporting numbers)
Summary · context
The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics.
Show in the study text Report a problemFND-2876553801
02AnimalAnimal study (in vivo)Mechanism
In rats with heat-stress liver injury, kisspeptin mainly attenuated the alteration of the fatty acid metabolism pathway in liver tissue.
In plain wordsIn heat-stressed rats, kisspeptin reduced heat-caused changes in a liver metabolic pathway called fatty acid metabolism.
Peptide
Kisspeptin-10
Outcome
DecreaseFatty acid metabolism alteration in liver
Study
ratn: not reported in source
Heat-stress liver injury
Outcome group
Metabolic pathways and metabolomics · Liver
Studied dose
Dose not stated
Source sentences
Summary
Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways.
1 context sentence(design, population, supporting numbers)
Summary · context
The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics.
Show in the study text Report a problemFND-2876553802
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with heat-stress liver injury, kisspeptin increased the level of GSH.
In plain wordsIn heat-stressed rats, kisspeptin raised an antioxidant molecule called GSH.
Peptide
Kisspeptin-10
Outcome
IncreaseGlutathione (GSH) level
Study
ratn: not reported in source
Heat-stress liver injury
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated
Source sentences
Summary
Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics.
Show in the study text Report a problemFND-2876553803
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with heat-stress liver injury, kisspeptin increased the level of T-AOC.
In plain wordsIn heat-stressed rats, kisspeptin raised total antioxidant capacity.
Peptide
Kisspeptin-10
Outcome
IncreaseTotal antioxidant capacity (T-AOC)
Study
ratn: not reported in source
Heat-stress liver injury
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated
Source sentences
Summary
Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics.
Show in the study text Report a problemFND-2876553804
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with heat-stress liver injury, kisspeptin increased SOD activity.
In plain wordsIn heat-stressed rats, kisspeptin raised the activity of an antioxidant enzyme called SOD.
Peptide
Kisspeptin-10
Outcome
IncreaseSuperoxide dismutase (SOD) activity
Study
ratn: not reported in source
Heat-stress liver injury
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated
Source sentences
Summary
Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics.
Show in the study text Report a problemFND-2876553805
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with heat-stress liver injury, the abstract reports that kisspeptin upregulated MDA levels.
In plain wordsIn heat-stressed rats, the abstract reports that kisspeptin raised MDA, a marker of oxidative damage.
Peptide
Kisspeptin-10
Outcome
IncreaseMalondialdehyde (MDA) level
Study
ratn: not reported in source
Heat-stress liver injury
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated
Source sentences
Summary
Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics.
Show in the study text Report a problemFND-2876553806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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