Thymosin beta-4 overexpression correlates with high-risk groups in gastric gastrointestinal stromal tumors: A retrospective analysis by immunohistochemistry.

Şahin S, Ekinci O, Seçkin S, Dursun A

Pathology, research and practice6 Jul 2017Cited by 2 (Europe PMC)

PMID28756979DOI10.1016/j.prp.2017.07.005PepBankPUB-28756979

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In 57 gastric GISTs, Tβ4 expression was directly correlated with higher risk groups, and this held in multivariate analysis.
In plain wordsIn gastric tumors, higher levels of the body's own thymosin beta‑4 were linked to higher-risk tumor groups.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTβ4 expression and tumor risk group
Study
n = 57
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tβ4 expression was found to be directly corrrelated with higher risk groups, tumor size, mitotic count, cellularity, and necrosis while it was inversely correlated with overall survival (OS) by univariate analysis (p=0.000, p=0.001, p=0.000, p=0.025, p=0.023, and p=0.042, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
The direct association between Tβ4 expression and risk groups were also supported by multivariate analysis (p=0.000, β=0.497, t=4.374).
Summary · context
Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2875697901
02HumanEndogenous levelObservational studyOther
In gastric GISTs, Tβ4 expression was directly correlated with tumor size.
In plain wordsIn gastric tumors, higher levels of the body's own thymosin beta‑4 were linked to larger tumors.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTβ4 expression and tumor size
Study
n = 57
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tβ4 expression was found to be directly corrrelated with higher risk groups, tumor size, mitotic count, cellularity, and necrosis while it was inversely correlated with overall survival (OS) by univariate analysis (p=0.000, p=0.001, p=0.000, p=0.025, p=0.023, and p=0.042, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2875697902
03HumanEndogenous levelObservational studyOther
In gastric GISTs, Tβ4 expression was directly correlated with mitotic count.
In plain wordsIn gastric tumors, higher levels of the body's own thymosin beta‑4 were linked to more dividing cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTβ4 expression and mitotic count
Study
n = 57
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tβ4 expression was found to be directly corrrelated with higher risk groups, tumor size, mitotic count, cellularity, and necrosis while it was inversely correlated with overall survival (OS) by univariate analysis (p=0.000, p=0.001, p=0.000, p=0.025, p=0.023, and p=0.042, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2875697903
04HumanEndogenous levelObservational studyOther
In gastric GISTs, Tβ4 expression was directly correlated with tumor cellularity.
In plain wordsIn gastric tumors, higher levels of the body's own thymosin beta‑4 were linked to denser tumor cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTβ4 expression and cellularity
Study
n = 57
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tβ4 expression was found to be directly corrrelated with higher risk groups, tumor size, mitotic count, cellularity, and necrosis while it was inversely correlated with overall survival (OS) by univariate analysis (p=0.000, p=0.001, p=0.000, p=0.025, p=0.023, and p=0.042, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2875697904
05HumanEndogenous levelObservational studyOther
In gastric GISTs, Tβ4 expression was directly correlated with tumor necrosis.
In plain wordsIn gastric tumors, higher levels of the body's own thymosin beta‑4 were linked to more tumor tissue death.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTβ4 expression and tumor necrosis
Study
n = 57
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tβ4 expression was found to be directly corrrelated with higher risk groups, tumor size, mitotic count, cellularity, and necrosis while it was inversely correlated with overall survival (OS) by univariate analysis (p=0.000, p=0.001, p=0.000, p=0.025, p=0.023, and p=0.042, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2875697905
06HumanEndogenous levelObservational studyOther
In gastric GISTs, Tβ4 expression was inversely correlated with overall survival in univariate analysis.
In plain wordsIn gastric tumors, higher levels of the body's own thymosin beta‑4 were linked to shorter survival.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTβ4 expression and overall survival
Study
n = 57
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tβ4 expression was found to be directly corrrelated with higher risk groups, tumor size, mitotic count, cellularity, and necrosis while it was inversely correlated with overall survival (OS) by univariate analysis (p=0.000, p=0.001, p=0.000, p=0.025, p=0.023, and p=0.042, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2875697906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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