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Study · Animal study (in vivo) · donkey, horse and mule · 2017

4 results

Effect of kisspeptin-10, LH and hCG on serum testosterone concentrations in stallions, donkeys and mules.

Akhtar RW, Shah SAH, Qureshi IZ

Theriogenology21 Jul 2017Cited by 5 (Europe PMC)

PMID28753433 (opens in a new tab)DOI10.1016/j.theriogenology.2017.07.027 (opens in a new tab)PepBankPUB-28753433
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In stallions, intravenous kisspeptin‑10 raised serum testosterone at 240 min compared with the pre-dose concentration.

    In plain wordsIn stallions, kisspeptin‑10 raised blood testosterone at 240 minutes compared with before the dose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone in stallions
    Study

    horsen: not reported in source

    Comparator
    Pre-dose concentration
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenousAs given in this study (horse).

    Source sentences

    Summary
    The administration of KP-10 and hCG to stallions resulted in a significant increase in serum T concentration at 240 min
    2 context sentences
    Summary · context
    This study was conducted to determine the response of serum testosterone (T) in male equines (stallions, donkeys and mules) after administering intravenous doses of kisspeptin-10 (KP-10), human chorionic gonadotropin (hCG) and luteinizing hormone (LH) and saline as a control.
    Summary · context
    The animals were divided into four groups of three each: Group I, 3 ml of 0.95% saline; Group II, 50 μg KP-10; Group III, 2500 IU hCG and group IV, 400 μg LH.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In donkeys, intravenous kisspeptin‑10 raised serum testosterone at 120 min compared with the pre-dose concentration.

    In plain wordsIn donkeys, kisspeptin‑10 raised blood testosterone at 120 minutes compared with before the dose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone in donkeys versus pre-dose
    Study

    donkeyn: not reported in source

    Comparator
    Pre-dose concentration
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenousAs given in this study (donkey).

    Source sentences

    Summary
    Both KP-10 and hCG significantly elevated the T concentrations in donkeys at 120 and 240 min, respectively; whereas it was significantly higher at 60, 120, and 240 min with LH treatment as compared to pre-dose concentration.
    2 context sentences
    Summary · context
    This study was conducted to determine the response of serum testosterone (T) in male equines (stallions, donkeys and mules) after administering intravenous doses of kisspeptin-10 (KP-10), human chorionic gonadotropin (hCG) and luteinizing hormone (LH) and saline as a control.
    Summary · context
    The animals were divided into four groups of three each: Group I, 3 ml of 0.95% saline; Group II, 50 μg KP-10; Group III, 2500 IU hCG and group IV, 400 μg LH.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In donkeys, intravenous kisspeptin‑10 raised testosterone at 240 min compared with the saline control and with hCG.

    In plain wordsIn donkeys, kisspeptin‑10 raised blood testosterone at 240 minutes more than saline or hCG.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone in donkeys versus control
    Study

    donkeyn: not reported in source

    Comparator
    Saline control and hCG
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenousAs given in this study (donkey).

    Source sentences

    Summary
    Both KP-10 and LH elevated T in donkeys at 240 min as compared to the control and hCG concentrations.
    2 context sentences
    Summary · context
    This study was conducted to determine the response of serum testosterone (T) in male equines (stallions, donkeys and mules) after administering intravenous doses of kisspeptin-10 (KP-10), human chorionic gonadotropin (hCG) and luteinizing hormone (LH) and saline as a control.
    Summary · context
    The animals were divided into four groups of three each: Group I, 3 ml of 0.95% saline; Group II, 50 μg KP-10; Group III, 2500 IU hCG and group IV, 400 μg LH.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mules, intravenous kisspeptin‑10 gave higher serum testosterone than saline control at 120 and 240 min.

    In plain wordsIn mules, kisspeptin‑10 gave higher blood testosterone than saline at 120 and 240 minutes.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone in mules
    Study

    mulen: not reported in source

    Comparator
    Saline control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg · intravenousAs given in this study (mule).

    Source sentences

    Summary
    After 120 and 240 min, T concentrations in mules were higher (p < 0.05) with administration of KP-10, hCG and LH as compared to the control.
    2 context sentences
    Summary · context
    This study was conducted to determine the response of serum testosterone (T) in male equines (stallions, donkeys and mules) after administering intravenous doses of kisspeptin-10 (KP-10), human chorionic gonadotropin (hCG) and luteinizing hormone (LH) and saline as a control.
    Summary · context
    The animals were divided into four groups of three each: Group I, 3 ml of 0.95% saline; Group II, 50 μg KP-10; Group III, 2500 IU hCG and group IV, 400 μg LH.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    10 Oct 2026, 09:43 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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