In rats with spinal cord ischemia, preliminary Cortexin reduced neurological deficit versus aorta ligation alone.
In plain wordsIn rats with spinal cord ischemia, Cortexin reduced neurological deficit compared with aorta ligation alone.
- Outcome
- DecreaseNeurological deficit
- Study
ratn = 16
Spinal cord ischemia from infrarenal aorta ligation- Comparator
- Aorta ligation without Cortexin
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 0.15 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
A pronounced and significant effect of cortexin, which was clinically expressed in a decrease in neurological deficit (p=0.0095),
2 context sentences(design, population, supporting numbers)
Spinal cord ischemia was achieved by ligation of the infrarenal abdominal aorta in 16 rats stratified into two equal groups:
the ligation of infrarenal aorta was performed in the control group, aorta ligation was performed also in the experimental group with preliminary intraperitoneally administration of cortexin in a dose of 0.15 mg/kg 30 min before procedure.