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Study · Animal study (in vivo) · rat · 2017

5 results

High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction.

Thummasorn S, Shinlapawittayatorn K, Chattipakorn SC, Chattipakorn N

Cardiovascular therapeutics1 Oct 2017Cited by 39 (Europe PMC)

PMID28726291 (opens in a new tab)DOI10.1111/1755-5922.12289 (opens in a new tab)PepBankPUB-28726291
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats with myocardial ischemia/reperfusion injury, HNG given during ischemia increased humanin levels in the damaged myocardium.

    In plain wordsIn rats with heart injury, HNG given during ischemia raised humanin levels in the damaged heart muscle.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin level in damaged myocardium
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury (30-minute LAD occlusion, 120-minute reperfusion)
    Outcome group
    Pharmacokinetics · Cardiovascular
    Studied dose
    252 μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HNG (252 μg/kg) applied during the ischemic period not only increased HN levels in the damaged myocardium, but also significantly decreased cardiac arrhythmia, myocardial infarct size, cardiac mitochondrial dysfunction, and left ventricular dysfunction.
    2 context sentences
    Summary · context
    Myocardial I/R injury was induced in rats by 30-minute left anterior descending coronary artery occlusion, followed by 120-minute of reperfusion.
    Summary · context
    HNG at the different doses were given intravenously at 15 minutes after ischemic onset and also at the onset of reperfusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial ischemia/reperfusion injury, HNG given during ischemia significantly decreased cardiac arrhythmia.

    In plain wordsIn rats with heart injury, HNG given during ischemia reduced irregular heartbeats.

    Peptide
    Humanin
    Outcome
    DecreaseCardiac arrhythmia
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury (30-minute LAD occlusion, 120-minute reperfusion)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    252 μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HNG (252 μg/kg) applied during the ischemic period not only increased HN levels in the damaged myocardium, but also significantly decreased cardiac arrhythmia, myocardial infarct size, cardiac mitochondrial dysfunction, and left ventricular dysfunction.
    2 context sentences
    Summary · context
    Myocardial I/R injury was induced in rats by 30-minute left anterior descending coronary artery occlusion, followed by 120-minute of reperfusion.
    Summary · context
    HNG at the different doses were given intravenously at 15 minutes after ischemic onset and also at the onset of reperfusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial ischemia/reperfusion injury, HNG given during ischemia significantly decreased myocardial infarct size.

    In plain wordsIn rats with heart injury, HNG given during ischemia reduced the size of the damaged heart area.

    Peptide
    Humanin
    Outcome
    DecreaseMyocardial infarct size
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury (30-minute LAD occlusion, 120-minute reperfusion)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    252 μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HNG (252 μg/kg) applied during the ischemic period not only increased HN levels in the damaged myocardium, but also significantly decreased cardiac arrhythmia, myocardial infarct size, cardiac mitochondrial dysfunction, and left ventricular dysfunction.
    2 context sentences
    Summary · context
    Myocardial I/R injury was induced in rats by 30-minute left anterior descending coronary artery occlusion, followed by 120-minute of reperfusion.
    Summary · context
    HNG at the different doses were given intravenously at 15 minutes after ischemic onset and also at the onset of reperfusion.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial ischemia/reperfusion injury, HNG given during ischemia significantly decreased cardiac mitochondrial dysfunction.

    In plain wordsIn rats with heart injury, HNG given during ischemia reduced mitochondrial dysfunction in the heart.

    Peptide
    Humanin
    Outcome
    DecreaseCardiac mitochondrial dysfunction
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury (30-minute LAD occlusion, 120-minute reperfusion)
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    252 μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HNG (252 μg/kg) applied during the ischemic period not only increased HN levels in the damaged myocardium, but also significantly decreased cardiac arrhythmia, myocardial infarct size, cardiac mitochondrial dysfunction, and left ventricular dysfunction.
    2 context sentences
    Summary · context
    Myocardial I/R injury was induced in rats by 30-minute left anterior descending coronary artery occlusion, followed by 120-minute of reperfusion.
    Summary · context
    HNG at the different doses were given intravenously at 15 minutes after ischemic onset and also at the onset of reperfusion.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial ischemia/reperfusion injury, HNG given during ischemia significantly decreased left ventricular dysfunction.

    In plain wordsIn rats with heart injury, HNG given during ischemia reduced weakness of the left heart chamber.

    Peptide
    Humanin
    Outcome
    DecreaseLeft ventricular dysfunction
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury (30-minute LAD occlusion, 120-minute reperfusion)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    252 μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HNG (252 μg/kg) applied during the ischemic period not only increased HN levels in the damaged myocardium, but also significantly decreased cardiac arrhythmia, myocardial infarct size, cardiac mitochondrial dysfunction, and left ventricular dysfunction.
    2 context sentences
    Summary · context
    Myocardial I/R injury was induced in rats by 30-minute left anterior descending coronary artery occlusion, followed by 120-minute of reperfusion.
    Summary · context
    HNG at the different doses were given intravenously at 15 minutes after ischemic onset and also at the onset of reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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