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Study · Animal study (in vivo) · rat · 2017

5 results

Neuroprotective effect of G14-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats.

Gao G, Fan H, Zhang X, Zhang F, Wu H, Qi F, Zhao L, Li Y

Neurological research18 Jul 2017Cited by 14 (Europe PMC)

PMID28720038 (opens in a new tab)DOI10.1080/01616412.2017.1352187 (opens in a new tab)PepBankPUB-28720038
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with global cerebral ischemia/reperfusion, HNG treatment decreased Bax expression compared with the untreated GI group.

    In plain wordsIn rats with brain ischemia, HNG treatment lowered a cell-death marker, Bax, compared with untreated rats.

    Peptide
    Humanin
    Outcome
    DecreaseBax expression (immunohistochemistry)
    Study

    ratn: not reported in source

    global cerebral ischemia/reperfusion (GI)
    Comparator
    GI group without HNG
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while Bax (0.26 ± 0.01 vs. 0.29 ± 0.008, P < 0.01) and Caspase-3 (0.20 ± 0.008 vs. 0.24 ± 0.02, P < 0.01) were significantly decreased by HNG-treatment compared with GI group.
    1 context sentence
    Summary · context
    Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with global cerebral ischemia/reperfusion, HNG treatment decreased Caspase-3 expression compared with the untreated GI group.

    In plain wordsIn rats with brain ischemia, HNG treatment lowered a cell-death marker, Caspase-3, compared with untreated rats.

    Peptide
    Humanin
    Outcome
    DecreaseCaspase-3 expression (immunohistochemistry)
    Study

    ratn: not reported in source

    global cerebral ischemia/reperfusion (GI)
    Comparator
    GI group without HNG
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while Bax (0.26 ± 0.01 vs. 0.29 ± 0.008, P < 0.01) and Caspase-3 (0.20 ± 0.008 vs. 0.24 ± 0.02, P < 0.01) were significantly decreased by HNG-treatment compared with GI group.
    1 context sentence
    Summary · context
    Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with global cerebral ischemia/reperfusion, HNG administration up-regulated STAT3 protein and mRNA levels.

    In plain wordsIn rats with brain ischemia, HNG raised the protein and mRNA levels of STAT3.

    Peptide
    Humanin
    Outcome
    IncreaseSTAT3 protein and mRNA levels
    Study

    ratn: not reported in source

    global cerebral ischemia/reperfusion (GI)
    Comparator
    GI group without HNG
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Along with immunohistochemistry, western blot and qRT-PCR indicated that the protein and mRNA levels of STAT3, MCL-1, and SOCS3 were up-regulated after administration of HNG at six time points after global cerebral I/R in rat.
    1 context sentence
    Summary · context
    Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with global cerebral ischemia/reperfusion, HNG administration up-regulated MCL-1 protein and mRNA levels.

    In plain wordsIn rats with brain ischemia, HNG raised the protein and mRNA levels of MCL-1.

    Peptide
    Humanin
    Outcome
    IncreaseMCL-1 protein and mRNA levels
    Study

    ratn: not reported in source

    global cerebral ischemia/reperfusion (GI)
    Comparator
    GI group without HNG
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Along with immunohistochemistry, western blot and qRT-PCR indicated that the protein and mRNA levels of STAT3, MCL-1, and SOCS3 were up-regulated after administration of HNG at six time points after global cerebral I/R in rat.
    1 context sentence
    Summary · context
    Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with global cerebral ischemia/reperfusion, HNG administration up-regulated SOCS3 protein and mRNA levels.

    In plain wordsIn rats with brain ischemia, HNG raised the protein and mRNA levels of SOCS3.

    Peptide
    Humanin
    Outcome
    IncreaseSOCS3 protein and mRNA levels
    Study

    ratn: not reported in source

    global cerebral ischemia/reperfusion (GI)
    Comparator
    GI group without HNG
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Along with immunohistochemistry, western blot and qRT-PCR indicated that the protein and mRNA levels of STAT3, MCL-1, and SOCS3 were up-regulated after administration of HNG at six time points after global cerebral I/R in rat.
    1 context sentence
    Summary · context
    Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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