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Study · Not a test of the peptide alone · 2017

2 results

Cross-Linking Furan-Modified Kisspeptin-10 to the KISS Receptor.

Vannecke W, Ampe C, Van Troys M, Beltramo M, Madder A

ACS chemical biology17 Jul 2017Cited by 21 (Europe PMC)

PMID28714670 (opens in a new tab)DOI10.1021/acschembio.7b00396 (opens in a new tab)PepBankPUB-28714670
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Activity measurement

    In live cells, furan-modified kisspeptin‑10 was covalently coupled to its glycosylated membrane receptor GPR54 (KISS1R).

    In plain wordsIn cells, a chemically modified kisspeptin‑10 attached itself permanently to its receptor.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableCovalent cross-linking of furan-modified kisspeptin-10 to KISS1R
    Study

    n: not reported in source

    Live cells
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We here describe, with live cells and under normal growth conditions, selective cross-linking of a furan-modified peptide ligand to its membrane-presented receptor with zero toxicity, high efficiency, and spatio-specificity. Furan-modified kisspeptin-10 is covalently coupled to its glycosylated memb…

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Activity measurement

    In several cell lines, the furan group of the modified kisspeptin‑10 oxidised spontaneously, with selective cross-link formation.

    In plain wordsIn cells, the modified kisspeptin‑10 linked to its receptor without any added chemical trigger.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableSpontaneous furan oxidation and cross-link formation
    Study

    n: not reported in source

    Live cells
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In contrast, we here show, for multiple cell lines, the spontaneous endogenous oxidation of the furan moiety with concurrent selective cross-link formation.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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