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Study · Animal study (in vivo) · rat · 2017

6 results

Chelating effects of carnosine in ameliorating nickel-induced nephrotoxicity in rats.

Hasanein P, Felegari Z

Canadian journal of physiology and pharmacology4 Jul 2017Cited by 27 (Europe PMC)

PMID28675793 (opens in a new tab)DOI10.1139/cjpp-2016-0647 (opens in a new tab)PepBankPUB-28675793
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In nickel-exposed rats, carnosine prevented the prooxidant and antioxidant imbalance.

    In plain wordsIn rats exposed to nickel, carnosine prevented the imbalance between oxidants and antioxidants.

    Peptide
    L-carnosine
    Outcome
    MixedProoxidant and antioxidant imbalance
    Study

    ratn: not reported in source

    Nickel-induced nephrotoxicity
    Comparator
    Nickel-treated rats
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    10 mg/kg/day · intragastric · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Carnosine prevented the prooxidant and antioxidant imbalance induced by nickel.
    2 context sentences
    Summary · context
    We investigated the protective effects of carnosine on nickel-induced oxidative stress in kidney of rats.
    Summary · context
    Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or) carnosine (10 mg·kg-1·day-1 intragastrically) for 21 days and then were evaluated for biochemical, molecular, and histopathological alterations.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In nickel-exposed rats, carnosine reduced kidney nickel concentration.

    In plain wordsIn rats exposed to nickel, carnosine reduced nickel accumulation in the kidneys.

    Peptide
    L-carnosine
    Outcome
    DecreaseKidney nickel concentration
    Study

    ratn: not reported in source

    Nickel-induced nephrotoxicity
    Comparator
    Nickel-treated rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 mg/kg/day · intragastric · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Nickel markedly accumulated in kidney of exposed rats, but its concentration was effectively reduced by carnosine treatment.
    2 context sentences
    Summary · context
    We investigated the protective effects of carnosine on nickel-induced oxidative stress in kidney of rats.
    Summary · context
    Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or) carnosine (10 mg·kg-1·day-1 intragastrically) for 21 days and then were evaluated for biochemical, molecular, and histopathological alterations.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In nickel-treated rats, carnosine corrected biochemical abnormalities.

    In plain wordsIn rats treated with nickel, carnosine corrected abnormal biochemical results.

    Peptide
    L-carnosine
    Outcome
    MixedBiochemical abnormalities
    Study

    ratn: not reported in source

    Nickel-induced nephrotoxicity
    Comparator
    Nickel-treated rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 mg/kg/day · intragastric · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Carnosine corrected the biochemical abnormalities and the elevated renal TNF-α and IL-6 levels in the nickel-treated group.
    2 context sentences
    Summary · context
    We investigated the protective effects of carnosine on nickel-induced oxidative stress in kidney of rats.
    Summary · context
    Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or) carnosine (10 mg·kg-1·day-1 intragastrically) for 21 days and then were evaluated for biochemical, molecular, and histopathological alterations.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In nickel-treated rats, carnosine corrected elevated renal TNF-α levels.

    In plain wordsIn rats treated with nickel, carnosine reduced elevated kidney TNF-alpha levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal TNF-alpha
    Study

    ratn: not reported in source

    Nickel-induced nephrotoxicity
    Comparator
    Nickel-treated rats
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    10 mg/kg/day · intragastric · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Carnosine corrected the biochemical abnormalities and the elevated renal TNF-α and IL-6 levels in the nickel-treated group.
    2 context sentences
    Summary · context
    We investigated the protective effects of carnosine on nickel-induced oxidative stress in kidney of rats.
    Summary · context
    Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or) carnosine (10 mg·kg-1·day-1 intragastrically) for 21 days and then were evaluated for biochemical, molecular, and histopathological alterations.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In nickel-treated rats, carnosine corrected elevated renal IL-6 levels.

    In plain wordsIn rats treated with nickel, carnosine reduced elevated kidney IL-6 levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal IL-6
    Study

    ratn: not reported in source

    Nickel-induced nephrotoxicity
    Comparator
    Nickel-treated rats
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    10 mg/kg/day · intragastric · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Carnosine corrected the biochemical abnormalities and the elevated renal TNF-α and IL-6 levels in the nickel-treated group.
    2 context sentences
    Summary · context
    We investigated the protective effects of carnosine on nickel-induced oxidative stress in kidney of rats.
    Summary · context
    Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or) carnosine (10 mg·kg-1·day-1 intragastrically) for 21 days and then were evaluated for biochemical, molecular, and histopathological alterations.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In nickel-exposed rats, carnosine attenuated abnormalities in renal architecture.

    In plain wordsIn rats exposed to nickel, carnosine reduced abnormalities in kidney structure.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal architecture
    Study

    ratn: not reported in source

    Nickel-induced nephrotoxicity
    Comparator
    Nickel-treated rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 mg/kg/day · intragastric · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    It also attenuated nickel-induced abnormalities in renal architecture.
    2 context sentences
    Summary · context
    We investigated the protective effects of carnosine on nickel-induced oxidative stress in kidney of rats.
    Summary · context
    Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or) carnosine (10 mg·kg-1·day-1 intragastrically) for 21 days and then were evaluated for biochemical, molecular, and histopathological alterations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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