Neuroprotective effect of carnosine against salsolinol-induced Parkinson's disease.

Zhao J, Shi L, Zhang LR

Experimental and therapeutic medicine8 Jun 2017Cited by 26 (Europe PMC)

PMID28672983PMCIDPMC5488497DOI10.3892/etm.2017.4571PepBankPUB-28672983

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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalOther designMechanism
In the rat brain and endothelial-cell study, carnosine renormalized antioxidant enzymes.
In plain wordsIn rats and rat cells, carnosine returned antioxidant enzymes toward normal levels.
Peptide
L-carnosine
Outcome
MixedAntioxidant enzymes
Study
ratn: not reported in source
Salsolinol-induced Parkinson's disease
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Antioxidant enzymes and lipid peroxidation levels were renormalized following treatment with carnosine.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study analyzed the protective effect of carnosine against Parkinson's disease in the salsolinol-induced rat brain and rat brain endothelial cells.
Report a problemFND-2867298302
02AnimalOther designMechanism
In the rat brain and endothelial-cell study, carnosine renormalized lipid peroxidation levels.
In plain wordsIn rats and rat cells, carnosine returned lipid oxidation levels toward normal.
Peptide
L-carnosine
Outcome
MixedLipid peroxidation
Study
ratn: not reported in source
Salsolinol-induced Parkinson's disease
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Antioxidant enzymes and lipid peroxidation levels were renormalized following treatment with carnosine.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study analyzed the protective effect of carnosine against Parkinson's disease in the salsolinol-induced rat brain and rat brain endothelial cells.
Report a problemFND-2867298303
03LabIn vitro (cells)Mechanism
In rat brain endothelial cells, carnosine reduced apoptosis in the salsolinol model.
In plain wordsIn cells from rat brains, carnosine reduced cell death in the salsolinol model.
Peptide
L-carnosine
Outcome
DecreaseEndothelial apoptosis
Study
ratn: not reported in source
Salsolinol-induced Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Fluorescence and confocal studies indicated reduced apoptosis in the endothelial cells of the rat brain tissue.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study analyzed the protective effect of carnosine against Parkinson's disease in the salsolinol-induced rat brain and rat brain endothelial cells.
Report a problemFND-2867298301
04LabIn vitro (cells)Mechanism
In rat brain endothelial cells, carnosine reduced mitochondria-derived ROS.
In plain wordsIn cells from rat brains, carnosine reduced reactive oxygen species from mitochondria.
Peptide
L-carnosine
Outcome
DecreaseMitochondrial ROS
Study
ratn: not reported in source
Salsolinol-induced Parkinson's disease
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, carnosine treatment reduced mitochondria-derived ROS in the rat brain endothelial cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study analyzed the protective effect of carnosine against Parkinson's disease in the salsolinol-induced rat brain and rat brain endothelial cells.
Report a problemFND-2867298304

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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