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Study · Animal study (in vivo) · rat · 2017

2 results

Nonsteroidal anti-inflammatory drugs-induced failure of lower esophageal and pyloric sphincter and counteraction of sphincters failure with stable gatric pentadecapeptide BPC 157 in rats.

Vitaic S, Stupnisek M, Drmic D, Bauk L, Kokot A, Klicek R, Vcev A, Luetic K, Seiwerth S, Sikiric P

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Apr 2017Cited by 12 (Europe PMC)

PMID28614776 (opens in a new tab)PepBankPUB-28614776
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given NSAIDs, BPC‑157 minimized the initial fall of lower esophageal sphincter pressure and restored pressure values to normal.

    In plain wordsIn rats given NSAIDs, BPC‑157 limited the drop in pressure of the lower food-pipe valve and restored it to normal.

    Peptide
    BPC-157
    Outcome
    IncreaseLower esophageal sphincter pressure
    Study

    ratn: not reported in source

    Rat NSAID-induced sphincter failure
    Comparator
    NSAID-treated controls
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal, intragastric or drinking waterAs given in this study (rat).

    Source sentences

    Summary
    By contrast, in all NSAIDs-rats that received BPC 157, initial fall of pressure was minimized and pressure values restored to normal values.
    3 context sentences
    Summary · context
    All tested NSAIDs decrease pressure in both sphincters, whilst BPC 157 counteracts their effects and restored both sphincters function.
    Summary · context
    We assessed lower esophageal sphincter and pyloric sphincter pressure (cmH2O) in rats treated with various NSAIDs regimens, at corresponding time points, known to produce stomach, small intestine lesions, hepatotoxicity and encephalopathy.
    Summary · context
    BPC 157 (10 μg/kg, 10 ng/kg) was given immediately after NSAIDs (intraperitoneally or intragastrically) or given in drinking water.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given NSAIDs, BPC‑157 minimized the initial fall of pyloric sphincter pressure and restored pressure values to normal.

    In plain wordsIn rats given NSAIDs, BPC‑157 limited the drop in pressure of the stomach outlet valve and restored it to normal.

    Peptide
    BPC-157
    Outcome
    IncreasePyloric sphincter pressure
    Study

    ratn: not reported in source

    Rat NSAID-induced sphincter failure
    Comparator
    NSAID-treated controls
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal, intragastric or drinking waterAs given in this study (rat).

    Source sentences

    Summary
    By contrast, in all NSAIDs-rats that received BPC 157, initial fall of pressure was minimized and pressure values restored to normal values.
    3 context sentences
    Summary · context
    All tested NSAIDs decrease pressure in both sphincters, whilst BPC 157 counteracts their effects and restored both sphincters function.
    Summary · context
    We assessed lower esophageal sphincter and pyloric sphincter pressure (cmH2O) in rats treated with various NSAIDs regimens, at corresponding time points, known to produce stomach, small intestine lesions, hepatotoxicity and encephalopathy.
    Summary · context
    BPC 157 (10 μg/kg, 10 ng/kg) was given immediately after NSAIDs (intraperitoneally or intragastrically) or given in drinking water.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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