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Study · Animal study (in vivo) · rat · 2015

8 results

[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].

Mendzheritsky AM, Karantysh GV, Ryzhak GA, Prokofiev VN

Advances in gerontology = Uspekhi gerontologii1 Jan 2015

PMID28509493 (opens in a new tab)PepBankPUB-28509493
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In aged rats under stress, Pinealon showed a less pronounced effect on brain free radical processes than Cortexin.

    In plain wordsIn rats under stress, Pinealon affected brain free radical processes less strongly than Cortexin.

    Peptide
    Pinealon
    Outcome
    Direction not reportedFree radical processes
    Study

    ratn: not reported in source

    18-month aged rats exposed to acute hypobaric hypoxia or mild hypothermia
    Comparator
    Cortexin
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon.
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In aged rats under stress, Pinealon showed a less pronounced effect on brain caspase 3 activity than Cortexin.

    In plain wordsIn rats under stress, Pinealon affected brain caspase activity less strongly than Cortexin.

    Peptide
    Pinealon
    Outcome
    Direction not reportedBrain caspase 3 activity
    Study

    ratn: not reported in source

    18-month aged rats exposed to acute hypobaric hypoxia or mild hypothermia
    Comparator
    Cortexin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon.
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aged rats with acute hypobaric hypoxia, Pinealon promoted adrenergic mediator accumulation in the brain.

    In plain wordsIn rats with acute hypobaric hypoxia, Pinealon increased accumulation of an adrenergic mediator in the brain.

    Peptide
    Pinealon
    Outcome
    IncreaseAdrenergic mediator accumulation
    Study

    ratn: not reported in source

    Aged rats with acute hypobaric hypoxia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia, as well as serotonin within cerebrum cortex in the model of mild hypothermia, which may underlie their geroprotective effects.
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In aged rats with mild hypothermia, Pinealon promoted serotonin accumulation in the cerebral cortex.

    In plain wordsIn rats with mild hypothermia, Pinealon increased serotonin accumulation in the brain cortex.

    Peptide
    Pinealon
    Outcome
    IncreaseCortical serotonin accumulation
    Study

    ratn: not reported in source

    Aged rats with mild hypothermia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia, as well as serotonin within cerebrum cortex in the model of mild hypothermia, which may underlie their geroprotective effects.
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In aged rats under stress, Cortexin affected brain free radical processes more strongly than Pinealon, with direction unspecified.

    In plain wordsIn rats under stress, Cortexin affected brain free radical processes more strongly than Pinealon. The abstract does not state the direction.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedFree radical processes
    Study

    ratn: not reported in source

    18-month aged rats under acute hypobaric hypoxia or mild hypothermia
    Comparator
    Pinealon
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon.
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In aged rats under stress, Cortexin affected brain caspase 3 activity more strongly than Pinealon, with direction unspecified.

    In plain wordsIn rats under stress, Cortexin affected brain caspase 3 activity more strongly than Pinealon. The abstract does not state the direction.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedCaspase 3 activity
    Study

    ratn: not reported in source

    18-month aged rats under acute hypobaric hypoxia or mild hypothermia
    Comparator
    Pinealon
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon.
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In aged rats under acute hypobaric hypoxia, Cortexin promoted adrenergic mediator accumulation in the brain.

    In plain wordsIn rats under acute hypobaric hypoxia, Cortexin promoted accumulation of an adrenergic messenger in the brain.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseAdrenergic mediator accumulation
    Study

    ratn: not reported in source

    Acute hypobaric hypoxia in aged rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia,
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In aged rats under mild hypothermia, Cortexin promoted serotonin accumulation in the cerebral cortex.

    In plain wordsIn rats under mild hypothermia, Cortexin promoted serotonin accumulation in the cerebral cortex.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseCortical serotonin accumulation
    Study

    ratn: not reported in source

    Mild hypothermia in aged rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia, as well as serotonin within cerebrum cortex in the model of mild hypothermia,
    1 context sentence
    Summary · context
    The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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