Glutathione and its antiaging and antimelanogenic effects.

Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P

Clinical, cosmetic and investigational dermatology27 Apr 2017Cited by 66 (Europe PMC)

PMID28490897PMCIDPMC5413479DOI10.2147/ccid.s128339PepBankPUB-28490897

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanRandomized controlled trialEfficacy outcome
In healthy women, GSH tended to lower melanin index versus placebo.
In plain wordsIn healthy women, GSH tended to lower skin pigment scores compared with placebo.
Peptide
Glutathione
Outcome
DecreaseMelanin index with GSH
Study
n: not reported in source
Comparator
Placebo
Outcome group
Pigmentation · Skin and wound
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
In generalized estimating equation analyses, melanin index and ultraviolet spots of all sites including face and arm when given GSH and GSSG tended to be lower than placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089701
02HumanRandomized controlled trialEfficacy outcome
In healthy women, GSSG tended to lower melanin index versus placebo.
In plain wordsIn healthy women, GSSG tended to lower skin pigment scores compared with placebo.
Peptide
Glutathione
Outcome
DecreaseMelanin index with GSSG
Study
n: not reported in source
Comparator
Placebo
Outcome group
Pigmentation · Skin and wound
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
In generalized estimating equation analyses, melanin index and ultraviolet spots of all sites including face and arm when given GSH and GSSG tended to be lower than placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089702
03HumanRandomized controlled trialEfficacy outcome
In healthy women, GSH tended to lower ultraviolet spots versus placebo.
In plain wordsIn healthy women, GSH tended to reduce ultraviolet spots compared with placebo.
Peptide
Glutathione
Outcome
DecreaseUltraviolet spots with GSH
Study
n: not reported in source
Comparator
Placebo
Outcome group
Skin and hair · Skin and wound
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
In generalized estimating equation analyses, melanin index and ultraviolet spots of all sites including face and arm when given GSH and GSSG tended to be lower than placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089703
04HumanRandomized controlled trialEfficacy outcome
In healthy women, GSSG tended to lower ultraviolet spots versus placebo.
In plain wordsIn healthy women, GSSG tended to reduce ultraviolet spots compared with placebo.
Peptide
Glutathione
Outcome
DecreaseUltraviolet spots with GSSG
Study
n: not reported in source
Comparator
Placebo
Outcome group
Skin and hair · Skin and wound
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
In generalized estimating equation analyses, melanin index and ultraviolet spots of all sites including face and arm when given GSH and GSSG tended to be lower than placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089704
05HumanRandomized controlled trialEfficacy outcome
In healthy women, GSH significantly reduced wrinkles at some sites versus placebo.
In plain wordsIn healthy women, GSH reduced wrinkles at some sites compared with placebo.
Peptide
Glutathione
Outcome
DecreaseWrinkles
Study
n: not reported in source
Comparator
Placebo
Outcome group
Skin and hair · Skin and wound
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
At some sites evaluated, subjects who received GSH showed a significant reduction in wrinkles compared with those taking placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089705
06HumanRandomized controlled trialEfficacy outcome
In healthy women, GSH tended to increase skin elasticity versus placebo.
In plain wordsIn healthy women, GSH tended to increase skin elasticity compared with placebo.
Peptide
Glutathione
Outcome
IncreaseSkin elasticity with GSH
Study
n: not reported in source
Comparator
Placebo
Outcome group
Skin and hair · Skin and wound
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
A tendency toward increased skin elasticity was observed in GSH and GSSG compared with placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089706
07HumanRandomized controlled trialEfficacy outcome
In healthy women, GSSG tended to increase skin elasticity versus placebo.
In plain wordsIn healthy women, GSSG tended to increase skin elasticity compared with placebo.
Peptide
Glutathione
Outcome
IncreaseSkin elasticity with GSSG
Study
n: not reported in source
Comparator
Placebo
Outcome group
Skin and hair · Skin and wound
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
A tendency toward increased skin elasticity was observed in GSH and GSSG compared with placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089707
08HumanRandomized controlled trialSafety outcome
In healthy women, no serious adverse effects occurred during the GSH and GSSG study.
In plain wordsIn healthy women, the GSH and GSSG study reported no serious adverse effects.
Peptide
Glutathione
Outcome
Not applicableSerious adverse effects
Study
n: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
250 mg/d · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
There were no serious adverse effects throughout the study.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted.
Summary · context
Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks.
Report a problemFND-2849089708

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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