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Study · In vitro (cells) · rat · 2017

4 results

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.

Cui AL, Zhang YH, Li JZ, Song T, Liu XM, Wang H, Zhang C, Ma GL, Zhang H, Li K

Drug design, development and therapy18 Apr 2017Cited by 23 (Europe PMC)

PMID28458518 (opens in a new tab)PMCIDPMC5402890 (opens in a new tab)DOI10.2147/dddt.s133042 (opens in a new tab)PepBankPUB-28458518
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In primary rat cortical neurons exposed to NMDA, humanin pretreatment increased mitochondrial succinate dehydrogenase activity.

    In plain wordsIn rat brain cells in a dish, humanin given before NMDA raised the activity of a mitochondrial enzyme.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial succinate dehydrogenase (SDH) activity
    Study

    ratn: not reported in source

    primary cultured rat cortical neurons with NMDA-induced excitotoxicity
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    1 μmol/LAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment of the neurons with HN (1 μmol/L) led to significant increases of mitochondrial succinate dehydrogenase (SDH) activity and membrane potential.
    1 context sentence
    Summary · context
    In this study, excitatory toxicity was induced by NMDA, which binds the NMDA receptor in primarily cultured rat cortical neurons.
  2. 02LabIn vitro (cells)Mechanism

    In primary rat cortical neurons exposed to NMDA, humanin pretreatment increased mitochondrial membrane potential.

    In plain wordsIn rat brain cells in a dish, humanin given before NMDA raised the membrane potential of mitochondria.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    ratn: not reported in source

    primary cultured rat cortical neurons with NMDA-induced excitotoxicity
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    1 μmol/LAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment of the neurons with HN (1 μmol/L) led to significant increases of mitochondrial succinate dehydrogenase (SDH) activity and membrane potential.
    1 context sentence
    Summary · context
    In this study, excitatory toxicity was induced by NMDA, which binds the NMDA receptor in primarily cultured rat cortical neurons.
  3. 03LabIn vitro (cells)Mechanism

    In primary rat cortical neurons exposed to NMDA, humanin pretreatment reduced excessive production of reactive oxygen species.

    In plain wordsIn rat brain cells in a dish, humanin given before NMDA lowered the excess production of reactive oxygen species.

    Peptide
    Humanin
    Outcome
    DecreaseReactive oxygen species production
    Study

    ratn: not reported in source

    primary cultured rat cortical neurons with NMDA-induced excitotoxicity
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    1 μmol/LAs given in this study (rat).

    Source sentences

    Summary
    In addition, HN pretreatment significantly reduced the excessive production of both reactive oxygen species (ROS) and nitric oxide (NO).
    1 context sentence
    Summary · context
    In this study, excitatory toxicity was induced by NMDA, which binds the NMDA receptor in primarily cultured rat cortical neurons.
  4. 04LabIn vitro (cells)Mechanism

    In primary rat cortical neurons exposed to NMDA, humanin pretreatment reduced excessive production of nitric oxide.

    In plain wordsIn rat brain cells in a dish, humanin given before NMDA lowered the excess production of nitric oxide.

    Peptide
    Humanin
    Outcome
    DecreaseNitric oxide production
    Study

    ratn: not reported in source

    primary cultured rat cortical neurons with NMDA-induced excitotoxicity
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    1 μmol/LAs given in this study (rat).

    Source sentences

    Summary
    In addition, HN pretreatment significantly reduced the excessive production of both reactive oxygen species (ROS) and nitric oxide (NO).
    1 context sentence
    Summary · context
    In this study, excitatory toxicity was induced by NMDA, which binds the NMDA receptor in primarily cultured rat cortical neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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