In patients with sacrococcygeal pilonidal sinus disease, endogenous Tβ4 expression in the epidermis was higher in inflamed sinus tract tissue than in noninflamed tissue.
In plain wordsIn people with pilonidal sinus disease, the body's own Tβ4 was higher in inflamed skin than in nearby normal skin.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseTβ4 expression score in epidermis
- Study
n = 31
- Comparator
- Noninflamed normal tissue adjacent to the sinus tract
- Outcome group
- Inflammation markers · Skin and wound
Measurements
- Tβ4 expression score
- 2.4 score
- inflamed sinus tract epidermis
- Tβ4 expression score
- 0.8 score
- noninflamed epidermis
Source sentences
Inflamed sinus tract tissue had significantly higher Tβ4 expression scores than noninflamed tissue samples in the epidermis (2.4 ± 0.8 [1.0-3.0] versus 0.8 ± 0.5 [0.0-2.0], P = .000), dermal/subcutaneous collagen (2.6 ± 0.5 [2.0-3.0] versus 1.6 ± 0.5 [1.0-2.0], P = .000), and vascular structure (2.6…
2 context sentences(design, population, supporting numbers)
Two (2) samples were cut from each specimen and prepared for histopathological assessment: 1 from the inflamed sinus tracts containing hair and granulation tissue (chronic wound group) and 1 from the normal tissue at least 1 cm away from the sinus tract (control group).
A total of 31 excisional skin biopsy specimens were available from 31 patients with SPSD (mean age 26.0 ± 7.6 years, 25 [80.6%] men, 6 [19.4%] women) who underwent primary surgical closure.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.