Thymosin β4 promotes the survival and angiogenesis of transplanted endothelial progenitor cells in the infarcted myocardium.

Quan Z, Wang QL, Zhou P, Wang GD, Tan YZ, Wang HJ

International journal of molecular medicine11 Apr 2017Cited by 16 (Europe PMC)

PMID28440414PMCIDPMC5428935DOI10.3892/ijmm.2017.2950PepBankPUB-28440414

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial infarction, transplanted Tβ4-treated EPCs improved cardiac function.
In plain wordsIn rats with a heart attack, transplanted cells pretreated with Tβ4 improved heart function.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCardiac function after transplantation of Tβ4-treated EPCs
Study
ratn: not reported in source
myocardial infarction by coronary ligation
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · intramyocardial injection of Tβ4-treated EPCsAs given in this study (rat).
Source sentences
Summary
Tβ4-treated EPCs improved cardiac function, enhanced the repair of the infarcted myocardium, and promoted angiogenesis after transplantation in the infarcted myocardium.
1 context sentence(design, population, supporting numbers)
Summary · context
Rat models of myocardial infarction (MI) were established by ligation of the anterior descending branch of the left coronary artery.
Report a problemFND-2844041408
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial infarction, transplanted Tβ4-treated EPCs enhanced repair of the infarcted myocardium.
In plain wordsIn rats with a heart attack, transplanted cells pretreated with Tβ4 helped repair the damaged heart muscle.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseRepair of infarcted myocardium after transplantation of Tβ4-treated EPCs
Study
ratn: not reported in source
myocardial infarction by coronary ligation
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · intramyocardial injection of Tβ4-treated EPCsAs given in this study (rat).
Source sentences
Summary
Tβ4-treated EPCs improved cardiac function, enhanced the repair of the infarcted myocardium, and promoted angiogenesis after transplantation in the infarcted myocardium.
1 context sentence(design, population, supporting numbers)
Summary · context
Rat models of myocardial infarction (MI) were established by ligation of the anterior descending branch of the left coronary artery.
Report a problemFND-2844041409
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial infarction, transplanted Tβ4-treated EPCs promoted angiogenesis in the infarcted myocardium.
In plain wordsIn rats with a heart attack, transplanted cells pretreated with Tβ4 promoted new blood vessel growth in the damaged heart.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAngiogenesis in infarcted myocardium after transplantation of Tβ4-treated EPCs
Study
ratn: not reported in source
myocardial infarction by coronary ligation
Outcome group
Angiogenesis · Cardiovascular
Studied dose
Dose not stated · intramyocardial injection of Tβ4-treated EPCsAs given in this study (rat).
Source sentences
Summary
Tβ4-treated EPCs improved cardiac function, enhanced the repair of the infarcted myocardium, and promoted angiogenesis after transplantation in the infarcted myocardium.
1 context sentence(design, population, supporting numbers)
Summary · context
Rat models of myocardial infarction (MI) were established by ligation of the anterior descending branch of the left coronary artery.
Report a problemFND-2844041410
04LabIn vitro (cells)Efficacy outcome
In rat endothelial progenitor cells, Tβ4 enhanced cell viability versus DMEM control.
In plain wordsIn cells, Tβ4 helped rat progenitor cells stay alive better than control medium.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseEPC viability
Study
ratn: not reported in source
bone marrow endothelial progenitor cells
Comparator
DMEM control
Outcome group
Cell viability and death · Cardiovascular
Studied dose
0.05, 0.1 and 0.2 µMAs given in this study (rat).
Source sentences
Summary
Tβ4 enhanced EPC viability, protected the cells from apoptosis in hypoxia and serum deprivation, and promoted the proliferation and migration of the cells and formation of capillary-like structures in the cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Then the cells were treated with Tβ4 at different concentrations (0.05, 0.1 and 0.2 µM), and cells incubated with DMEM were set as controls.
Report a problemFND-2844041401
05LabIn vitro (cells)Efficacy outcome
In rat endothelial progenitor cells under hypoxia and serum deprivation, Tβ4 protected the cells from apoptosis.
In plain wordsIn cells, Tβ4 protected rat progenitor cells from dying under low oxygen and no serum.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseEPC apoptosis under hypoxia and serum deprivation
Study
ratn: not reported in source
bone marrow endothelial progenitor cells
Comparator
DMEM control
Outcome group
Cell viability and death · Cardiovascular
Studied dose
0.05, 0.1 and 0.2 µMAs given in this study (rat).
Source sentences
Summary
Tβ4 enhanced EPC viability, protected the cells from apoptosis in hypoxia and serum deprivation, and promoted the proliferation and migration of the cells and formation of capillary-like structures in the cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Then the cells were treated with Tβ4 at different concentrations (0.05, 0.1 and 0.2 µM), and cells incubated with DMEM were set as controls.
Report a problemFND-2844041402
06LabIn vitro (cells)Efficacy outcome
In rat endothelial progenitor cells, Tβ4 promoted proliferation.
In plain wordsIn cells, Tβ4 led rat progenitor cells to multiply more than in control medium.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseEPC proliferation
Study
ratn: not reported in source
bone marrow endothelial progenitor cells
Comparator
DMEM control
Outcome group
Cell viability and death · Cardiovascular
Studied dose
0.05, 0.1 and 0.2 µMAs given in this study (rat).
Source sentences
Summary
Tβ4 enhanced EPC viability, protected the cells from apoptosis in hypoxia and serum deprivation, and promoted the proliferation and migration of the cells and formation of capillary-like structures in the cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Then the cells were treated with Tβ4 at different concentrations (0.05, 0.1 and 0.2 µM), and cells incubated with DMEM were set as controls.
Report a problemFND-2844041403
07LabIn vitro (cells)Efficacy outcome
In rat endothelial progenitor cells, Tβ4 promoted migration.
In plain wordsIn cells, Tβ4 led rat progenitor cells to move more than in control medium.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseEPC migration
Study
ratn: not reported in source
bone marrow endothelial progenitor cells
Comparator
DMEM control
Outcome group
Angiogenesis · Cardiovascular
Studied dose
0.05, 0.1 and 0.2 µMAs given in this study (rat).
Source sentences
Summary
Tβ4 enhanced EPC viability, protected the cells from apoptosis in hypoxia and serum deprivation, and promoted the proliferation and migration of the cells and formation of capillary-like structures in the cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Then the cells were treated with Tβ4 at different concentrations (0.05, 0.1 and 0.2 µM), and cells incubated with DMEM were set as controls.
Report a problemFND-2844041404
08LabIn vitro (cells)Efficacy outcome
In rat endothelial progenitor cells, Tβ4 promoted formation of capillary-like structures.
In plain wordsIn cells, Tβ4 helped rat progenitor cells form tube-like structures more than control medium.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseFormation of capillary-like structures
Study
ratn: not reported in source
bone marrow endothelial progenitor cells
Comparator
DMEM control
Outcome group
Angiogenesis · Cardiovascular
Studied dose
0.05, 0.1 and 0.2 µMAs given in this study (rat).
Source sentences
Summary
Tβ4 enhanced EPC viability, protected the cells from apoptosis in hypoxia and serum deprivation, and promoted the proliferation and migration of the cells and formation of capillary-like structures in the cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Then the cells were treated with Tβ4 at different concentrations (0.05, 0.1 and 0.2 µM), and cells incubated with DMEM were set as controls.
Report a problemFND-2844041405
09LabIn vitro (cells)Mechanism
In rat endothelial progenitor cells, Tβ4 increased p-Akt expression.
In plain wordsIn cells, Tβ4 raised the level of an activated survival signal (p-Akt) in rat progenitor cells.
Peptide
Thymosin beta-4 (human)
Outcome
Increasep-Akt expression
Study
ratn: not reported in source
bone marrow endothelial progenitor cells
Comparator
DMEM control
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
0.05, 0.1 and 0.2 µMAs given in this study (rat).
Source sentences
Summary
Moreover, Tβ4 increased p-Akt expression in the cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Then the cells were treated with Tβ4 at different concentrations (0.05, 0.1 and 0.2 µM), and cells incubated with DMEM were set as controls.
Report a problemFND-2844041406
10LabIn vitro (cells)Efficacy outcome
In rat endothelial progenitor cells, the cytoprotective and proangiogenic effects of Tβ4 were dose-dependent.
In plain wordsIn cells, the protective and blood-vessel-promoting effects of Tβ4 grew with the dose.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseDose dependence of cytoprotective and proangiogenic effects
Study
ratn: not reported in source
bone marrow endothelial progenitor cells
Outcome group
Cell viability and death · Cardiovascular
Studied dose
0.05, 0.1 and 0.2 µMAs given in this study (rat).
Source sentences
Summary
The cytoprotective and proangiogenic effects of Tβ4 were in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
Then the cells were treated with Tβ4 at different concentrations (0.05, 0.1 and 0.2 µM), and cells incubated with DMEM were set as controls.
Report a problemFND-2844041407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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