In infertile patients undergoing frozen embryo transfer, triptorelin pretreatment increased implantation compared with estrogen and progesterone alone.
In plain wordsIn patients receiving frozen embryos, triptorelin pretreatment increased implantation compared with estrogen and progesterone alone.
- Outcome
- IncreaseImplantation rate
- Study
n = 210
- Comparator
- Estrogen and progesterone preparation without triptorelin
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- 0.1 mg daily, reduced to 0.05 mg · subcutaneousAs given in this study (human).
Measurements
- Implantation rate
- 44.1%
- triptorelin group
- Implantation rate
- 21.1%
- estrogen and progesterone only
Source sentences
There was a significant increase in implantation rate in the GnRh agonist group (group A) compared to the estrogen and progesterone only group (group B) (44.1 vs. 21.1 %; P = 0.002*).
3 context sentences(design, population, supporting numbers)
Prospective controlled study.
Group A patients consisted of 110 patients (110 cycles) who received daily subcutaneous injections of 0.1 mg of the GnRh agonist triptorelin starting from the mid-luteal phase of the cycle preceding the actual FET cycle.
Group B consisted of 100 patients (100 cycles) who started daily estradiol valerate 6 mg administration from the second day of the FET cycle and followed the same regimen but without prior treatment with triptorelin.