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Study · Non-randomized trial · 2017

11 results

Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts.

Valdivia A, Ly J, Gonzalez L, Hussain P, Saing T, Islamoglu H, Pearce D, Ochoa C, Venketaraman V

AIDS research and human retroviruses10 May 2017Cited by 42 (Europe PMC)

PMID28398068 (opens in a new tab)PMCIDPMC5576219 (opens in a new tab)DOI10.1089/aid.2016.0303 (opens in a new tab)PepBankPUB-28398068
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH increased IL-12 compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione increased IL-12 compared with placebo.

    Peptide
    Glutathione
    Outcome
    IncreaseIL-12
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  2. 02HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH increased IL-2 compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione increased IL-2 compared with placebo.

    Peptide
    Glutathione
    Outcome
    IncreaseIL-2
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  3. 03HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH increased IFN-γ compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione increased IFN-γ compared with placebo.

    Peptide
    Glutathione
    Outcome
    IncreaseIFN-γ
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  4. 04HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH decreased IL-6 compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione decreased IL-6 compared with placebo.

    Peptide
    Glutathione
    Outcome
    DecreaseIL-6
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  5. 05HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH decreased IL-10 compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione decreased IL-10 compared with placebo.

    Peptide
    Glutathione
    Outcome
    DecreaseIL-10
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  6. 06HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH decreased free radicals compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione decreased free radicals compared with placebo.

    Peptide
    Glutathione
    Outcome
    DecreaseFree radicals
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Oxidative stress · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  7. 07HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH stabilized TGF-β levels compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione stabilized TGF-β levels compared with placebo.

    Peptide
    Glutathione
    Outcome
    No significant changeTGF-β
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  8. 08HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH stabilized IL-1 levels compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione stabilized IL-1 levels compared with placebo.

    Peptide
    Glutathione
    Outcome
    No significant changeIL-1
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  9. 09HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects with low CD4 counts, liposomal GSH stabilized IL-17 levels compared with placebo.

    In plain wordsIn HIV-positive subjects with low CD4 counts, liposomal glutathione stabilized IL-17 levels compared with placebo.

    Peptide
    Glutathione
    Outcome
    No significant changeIL-17
    Study

    n: not reported in source

    Comparator
    Empty liposomal placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  10. 10HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects, CD4 T cell free radical levels stabilized in the liposomal GSH treatment group.

    In plain wordsIn HIV-positive subjects, free radical levels in CD4 T cells stabilized during liposomal glutathione treatment.

    Peptide
    Glutathione
    Outcome
    No significant changeCD4 T cell free radicals
    Study

    n: not reported in source

    Outcome group
    Oxidative stress · Immune and inflammation
    Studied dose
    Dose not stated · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Levels of free radicals in CD4+ T cells stabilized, while GSH levels increased in the treatment group.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.
  11. 11HumanNon-randomized trialEfficacy outcome

    In HIV-positive subjects, GSH levels increased in the liposomal GSH treatment group.

    In plain wordsIn HIV-positive subjects, glutathione levels increased from baseline during liposomal glutathione treatment.

    Peptide
    Glutathione
    Outcome
    IncreaseGSH levels
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Immune and inflammation
    Studied dose
    Dose not stated · oral · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    Levels of free radicals in CD4+ T cells stabilized, while GSH levels increased in the treatment group.
    1 context sentence
    Summary · context
    In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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