α-Estrogen and Progesterone Receptors Modulate Kisspeptin Effects on Prolactin: Role in Estradiol-Induced Prolactin Surge in Female Rats.

Aquino NSS, Araujo-Lopes R, Henriques PC, Lopes FEF, Gusmao DO, Coimbra CC, Franci CR, Reis AM, Reis AM, Szawka RE

Endocrinology1 Jun 2017Cited by 26 (Europe PMC)

PMID28387824DOI10.1210/en.2016-1855PepBankPUB-28387824

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats treated with estradiol, intracerebroventricular Kp-10 increased prolactin release.
In plain wordsIn rats, Kp-10 given into the brain increased prolactin release when estradiol was present.
Peptide
Kisspeptin-10
Outcome
IncreaseProlactin release in estradiol-treated OVX rats
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 increased PRL release and decreased 3,4-dihydroxyphenylacetic acid levels in the median eminence (ME) of OVX rats treated with estradiol (OVX+E)
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782401
02AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats treated with estradiol, intracerebroventricular Kp-10 decreased 3,4-dihydroxyphenylacetic acid levels in the median eminence.
In plain wordsIn rats given estradiol, Kp-10 lowered a dopamine breakdown product in a brain region.
Peptide
Kisspeptin-10
Outcome
DecreaseDOPAC level in median eminence
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 increased PRL release and decreased 3,4-dihydroxyphenylacetic acid levels in the median eminence (ME) of OVX rats treated with estradiol (OVX+E)
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782402
03AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats without estradiol, Kp-10 did not increase prolactin or lower DOPAC.
In plain wordsIn rats without estradiol, Kp-10 had none of the effects on prolactin seen with estradiol.
Peptide
Kisspeptin-10
Outcome
No significant changeKp-10 effects in OVX rats without estradiol
Study
ratn: not reported in source
Comparator
OVX+E rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Whereas these effects of Kp-10 were absent in OVX rats
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782404
04AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats treated with the ERα agonist propylpyrazole triol, the effects of Kp-10 on prolactin and DOPAC were replicated.
In plain wordsIn rats given an estrogen receptor alpha agonist, Kp-10 had the same effects on prolactin release as with estradiol.
Peptide
Kisspeptin-10
Outcome
IncreaseKp-10 effects with ERα agonist PPT
Study
ratn: not reported in source
Comparator
OVX rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
they were replicated in OVX rats treated with selective agonist of estrogen receptor (ER)α, propylpyrazole triol, but not of ERβ, diarylpropionitrile.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782405
05AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats treated with the ERβ agonist diarylpropionitrile, the effects of Kp-10 were not replicated.
In plain wordsIn rats given an estrogen receptor beta agonist, Kp-10 did not have the effects on prolactin seen with estradiol.
Peptide
Kisspeptin-10
Outcome
No significant changeKp-10 effects with ERβ agonist DPN
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
they were replicated in OVX rats treated with selective agonist of estrogen receptor (ER)α, propylpyrazole triol, but not of ERβ, diarylpropionitrile.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782406
06AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats treated with estradiol and progesterone, the Kp-10-induced prolactin increase was two times higher than in rats given estradiol alone.
In plain wordsIn rats, adding progesterone to estradiol doubled the prolactin increase caused by Kp-10.
Peptide
Kisspeptin-10
Outcome
IncreaseKp-10-induced prolactin increase with progesterone
Study
ratn: not reported in source
Comparator
OVX+E rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Furthermore, the Kp-10-induced increase in PRL was two times higher in OVX+E rats also treated with progesterone (OVX+EP)
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782407
07AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats treated with estradiol and progesterone, Kp-10 was associated with reduced expression of tyrosine hydroxylase and Ser40-phosphorylated tyrosine hydroxylase in the median eminence.
In plain wordsIn rats given estradiol and progesterone, Kp-10 went with lower levels of a dopamine-making enzyme in a brain region.
Peptide
Kisspeptin-10
Outcome
DecreaseTyrosine hydroxylase expression in median eminence
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Furthermore, the Kp-10-induced increase in PRL was two times higher in OVX+E rats also treated with progesterone (OVX+EP), which was associated with a reduced expression of both tyrosine hydroxylase (TH) and Ser40-phosphorylated TH in the ME.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782408
08AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats treated with estradiol and progesterone, Kp-10 reduced dopamine levels in the median eminence.
In plain wordsIn rats given estradiol and progesterone, Kp-10 lowered dopamine levels in a brain region.
Peptide
Kisspeptin-10
Outcome
DecreaseDopamine level in median eminence of OVX+EP rats
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 also reduced dopamine levels in the ME of OVX+EP rats
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
Report a problemFND-2838782409

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

09AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In ovariectomized rats treated with estradiol, tamoxifen prevented the Kp-10-induced prolactin increase and DOPAC decrease.
In plain wordsIn rats, tamoxifen stopped the effects of Kp-10 on prolactin release and a dopamine breakdown product.
Peptide
Kisspeptin-10
Outcome
DecreaseKp-10 effect on prolactin with tamoxifen
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
which was prevented by tamoxifen.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2838782403
10AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In ovariectomized rats treated with estradiol and progesterone, the progesterone receptor antagonist RU486 blocked the Kp-10-induced dopamine reduction.
In plain wordsIn rats, a progesterone receptor blocker stopped Kp-10 from lowering dopamine in a brain region.
Peptide
Kisspeptin-10
Outcome
IncreaseKp-10 dopamine reduction with RU486
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
an effect blocked by the progesterone receptor (PR) antagonist RU486.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracerebroventricular injections of Kp-10 or Kp-234 were performed in ovariectomized (OVX) rats under different hormonal treatments.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2838782410

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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