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Study · In vitro (cells) · 2017

7 results

Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation.

Gottardo MF, Moreno Ayala M, Ferraris J, Zárate S, Pisera D, Candolfi M, Jaita G, Seilicovich A

Journal of cell communication and signaling4 Apr 2017Cited by 22 (Europe PMC)

PMID28378125 (opens in a new tab)PMCIDPMC5704037 (opens in a new tab)DOI10.1007/s12079-017-0388-4 (opens in a new tab)PepBankPUB-28378125
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In normal and tumor pituitary cells, STAT3 inhibition reversed the inhibitory effect of HN on TNF-α-induced apoptosis.

    In plain wordsIn pituitary cells in the lab, blocking STAT3 removed the protective effect of humanin against TNF-α-induced cell death.

    Peptide
    Humanin
    Outcome
    Not applicableSTAT3 role in HN inhibition of TNF-α-induced apoptosis
    Study

    n: not reported in source

    anterior pituitary cells and GH3 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    STAT3 inhibition reversed the inhibitory effect of HN on TNF-α-induced apoptosis in normal and pituitary tumor cells
    1 context sentence
    Summary · context
    The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line.
  2. 02LabIn vitro (cells)Mechanism

    In normal anterior pituitary cells, inhibition of the NF-κB pathway did not affect the action of HN.

    In plain wordsIn normal pituitary cells in the lab, blocking NF-κB did not change the effect of humanin.

    Peptide
    Humanin
    Outcome
    No significant changeNF-κB role in HN action in normal pituitary cells
    Study

    n: not reported in source

    anterior pituitary cells and GH3 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Inhibition of NF-κB pathway did not affect action of HN on normal anterior pituitary cells
    1 context sentence
    Summary · context
    The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line.
  3. 03LabIn vitro (cells)Mechanism

    In GH3 tumor pituitary cells, inhibition of NF-κB blocked the cytoprotective effect of HN on TNF-α-induced apoptosis.

    In plain wordsIn pituitary tumor cells in the lab, blocking NF-κB removed the protective effect of humanin against TNF-α-induced cell death.

    Peptide
    Humanin
    Outcome
    Not applicableNF-κB role in HN cytoprotection in GH3 tumor cells
    Study

    n: not reported in source

    anterior pituitary cells and GH3 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but blocked the cytoprotective effect of HN on TNF-α-induced apoptosis of GH3 cells
    1 context sentence
    Summary · context
    The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line.
  4. 04LabIn vitro (cells)Mechanism

    In pituitary cells, HN induced NF-κB-p65 nuclear translocation.

    In plain wordsIn pituitary cells in the lab, humanin moved the NF-κB-p65 protein into the cell nucleus.

    Peptide
    Humanin
    Outcome
    IncreaseNF-κB-p65 nuclear translocation
    Study

    n: not reported in source

    anterior pituitary cells and GH3 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also induced NF-κB-p65 nuclear translocation in these cells.
    1 context sentence
    Summary · context
    The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line.
  5. 05LabIn vitro (cells)Mechanism

    In pituitary tumor cells, JNK and MEK inhibitors impaired the cytoprotective action of HN.

    In plain wordsIn pituitary tumor cells in the lab, blocking JNK or MEK weakened the protective effect of humanin.

    Peptide
    Humanin
    Outcome
    Not applicableJNK and MEK role in HN cytoprotection in pituitary tumor cells
    Study

    n: not reported in source

    anterior pituitary cells and GH3 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In pituitary tumor cells, JNK and MEK inhibitors also impaired HN cytoprotective action.
    1 context sentence
    Summary · context
    The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line.
  6. 06LabIn vitro (cells)Mechanism

    In pituitary cells, HN increased Bcl-2 expression.

    In plain wordsIn pituitary cells in the lab, humanin raised Bcl-2, a protein that protects cells from death.

    Peptide
    Humanin
    Outcome
    IncreaseBcl-2 expression
    Study

    n: not reported in source

    anterior pituitary cells and GH3 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HN increased Bcl-2 expression and decreased Bax mitochondrial translocation.
    1 context sentence
    Summary · context
    The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line.
  7. 07LabIn vitro (cells)Mechanism

    In pituitary cells, HN decreased Bax mitochondrial translocation.

    In plain wordsIn pituitary cells in the lab, humanin reduced movement of the cell death protein Bax to mitochondria.

    Peptide
    Humanin
    Outcome
    DecreaseBax mitochondrial translocation
    Study

    n: not reported in source

    anterior pituitary cells and GH3 cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HN increased Bcl-2 expression and decreased Bax mitochondrial translocation.
    1 context sentence
    Summary · context
    The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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