Effect of androgen on Kiss1 expression and luteinizing hormone release in female rats.

Iwata K, Kunimura Y, Matsumoto K, Ozawa H

The Journal of endocrinology4 Apr 2017Cited by 26 (Europe PMC)

PMID28377404DOI10.1530/joe-16-0568PepBankPUB-28377404

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female rats exposed to DHT, central injection of kisspeptin‑10 did not affect luteinizing hormone release.
In plain wordsIn female rats given DHT, kisspeptin‑10 injected into the brain did not change luteinizing hormone release.
Peptide
Kisspeptin-10
Outcome
No significant changeLH release after kisspeptin-10 in DHT rats
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · centralAs given in this study (rat).
Source sentences
Summary
Central injection of kisspeptin-10 or intravenous injection of a GnRH agonist did not affect the LH release in DHT rats
1 context sentence(design, population, supporting numbers)
Summary · context
Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age.
Report a problemFND-2837740405

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In female rats exposed to DHT, the number of Kiss1-expressing cells in the AVPV and ARC was significantly decreased.
In plain wordsIn female rats given DHT, the body's own kisspeptin-producing cells were fewer in two brain regions.
Peptide
Kisspeptin-10
Outcome
DecreaseKiss1-expressing cells in AVPV and ARC of ovary-intact DHT rats
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Number of Kiss1-expressing cells in both the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) was significantly decreased in ovary-intact DHT rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2837740401
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In female rats exposed to DHT and high estradiol, the number of AVPV Kiss1-expressing cells did not differ significantly from non-DHT rats.
In plain wordsIn female rats given DHT, natural kisspeptin cells in one brain region were not different from non-DHT rats under high estradiol.
Peptide
Kisspeptin-10
Outcome
No significant changeAVPV Kiss1-expressing cells under high estradiol
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
even though significant differences were not observed between DHT and non-DHT rats with regard to number of AVPV Kiss1-expressing cells or gonadotrophin-releasing hormone (GnRH)-immunoreactive (ir) cells in the presence of high estradiol.
1 context sentence(design, population, supporting numbers)
Summary · context
Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2837740402
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In ovariectomized female rats exposed to DHT, Kiss1-expressing cells were significantly decreased in the ARC compared with OVX non-DHT rats.
In plain wordsIn ovariectomized female rats given DHT, the body's own kisspeptin cells were fewer in a brain region than in rats without DHT.
Peptide
Kisspeptin-10
Outcome
DecreaseARC Kiss1-expressing cells in OVX DHT rats
Study
ratn: not reported in source
Comparator
OVX non-DHT rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Kiss1-expressing and neurokinin B-ir cells were significantly decreased in the ARC of ovariectomized (OVX) DHT rats compared with OVX non-DHT rats
1 context sentence(design, population, supporting numbers)
Summary · context
Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2837740403
05AnimalEndogenous levelAnimal study (in vivo)Mechanism
In female rats, ARC Kiss1-expressing cells expressed androgen receptors, whereas few AVPV Kiss1-expressing cells did.
In plain wordsIn female rats, the body's own kisspeptin cells in one brain region carried androgen receptors, but few did in another region.
Peptide
Kisspeptin-10
Outcome
Not applicableAndrogen receptor expression in Kiss1 cells
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Notably, ARC Kiss1-expressing cells expressed androgen receptors (ARs) in female rats, whereas only a few Kiss1-expressing cells expressed ARs in the AVPV.
1 context sentence(design, population, supporting numbers)
Summary · context
Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2837740404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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