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Study · Animal study (in vivo) · pig · 2017

6 results

The metabolic syndrome induces early changes in the swine renal medullary mitochondria.

Eirin A, Woollard JR, Ferguson CM, Jordan KL, Tang H, Textor SC, Lerman A, Lerman LO

Translational research : the journal of laboratory and clinical medicine11 Mar 2017Cited by 31 (Europe PMC)

PMID28363084 (opens in a new tab)PMCIDPMC5429873 (opens in a new tab)DOI10.1016/j.trsl.2017.03.002 (opens in a new tab)PepBankPUB-28363084
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In pigs with diet-induced metabolic syndrome, chronic elamipretide restored mitochondrial structure in the kidney.

    In plain wordsIn pigs with metabolic syndrome, elamipretide restored the structure of the energy-producing parts (mitochondria) of kidney cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal mitochondrial structure
    Study

    pign = 14

    diet-induced metabolic syndrome (MetS), 16 weeks
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elamipretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In pigs with diet-induced metabolic syndrome, chronic elamipretide restored mitochondrial ATP synthesis in the kidney.

    In plain wordsIn pigs with metabolic syndrome, elamipretide restored the energy (ATP) production of kidney cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal mitochondrial ATP synthesis
    Study

    pign = 14

    diet-induced metabolic syndrome (MetS), 16 weeks
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elamipretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In pigs with diet-induced metabolic syndrome, chronic elamipretide restored antioxidant defenses in the kidney.

    In plain wordsIn pigs with metabolic syndrome, elamipretide restored the antioxidant defences of kidney cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal antioxidant defenses
    Study

    pign = 14

    diet-induced metabolic syndrome (MetS), 16 weeks
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elamipretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In pigs with diet-induced metabolic syndrome, chronic elamipretide decreased mitochondrial oxidative stress in the kidney.

    In plain wordsIn pigs with metabolic syndrome, elamipretide lowered oxidative stress in the energy-producing parts of kidney cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial oxidative stress
    Study

    pign = 14

    diet-induced metabolic syndrome (MetS), 16 weeks
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elamipretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, chronic elamipretide decreased hypoxia in the renal medulla.

    In plain wordsIn pigs with metabolic syndrome, elamipretide lowered low-oxygen conditions in the inner part of the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMedullary hypoxia
    Study

    pign = 14

    diet-induced metabolic syndrome (MetS), 16 weeks
    Comparator
    Untreated MetS pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elamipretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, chronic elamipretide decreased renal injury.

    In plain wordsIn pigs with metabolic syndrome, elamipretide treatment reduced kidney injury.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal injury
    Study

    pign = 14

    diet-induced metabolic syndrome (MetS), 16 weeks
    Comparator
    Untreated MetS pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elamipretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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