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Study · Animal study (in vivo) · rat · 2017

6 results

Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.

Gultekin FA, Emre AU, Celik SK, Barut F, Tali U, Sumer D, Turkcu UO

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 Mar 2017Cited by 8 (Europe PMC)

PMID28361841 (opens in a new tab)PMCIDPMC5385712 (opens in a new tab)DOI10.4103/sjg.sjg_318_16 (opens in a new tab)PepBankPUB-28361841
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, HNG treatment significantly ameliorated weight loss.

    In plain wordsIn rats with induced colitis, HNG treatment reduced weight loss.

    Peptide
    Humanin
    Outcome
    DecreaseWeight loss in TNBS colitis
    Study

    ratn: not reported in source

    TNBS-induced colitis
    Comparator
    TNBS colitis group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 and 20 μM · intraperitoneal · 7 days (doses on day 2 and day 6)As given in this study (rat).

    Source sentences

    Summary
    HNG treatment significantly ameliorated weight loss and macroscopic and microscopic scores.
    1 context sentence
    Summary · context
    Rats were divided into four groups as follows: Group 1 (n = 8): control; isotonic saline solution 0.1 ml/rat rectally, Group 2 (n = 8): TNBS colitis; 0.1 ml of a 2.5% (w/v) TNBS solution in 50% ethanol rectally, Group 3 (n = 8): 10 μM HNG, and Group 4 (n = 8): 20 μM HNG intraperitoneal (ip) on day 2…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, HNG treatment significantly ameliorated the macroscopic score.

    In plain wordsIn rats with induced colitis, HNG treatment improved the visible damage score of the colon.

    Peptide
    Humanin
    Outcome
    DecreaseMacroscopic colitis score
    Study

    ratn: not reported in source

    TNBS-induced colitis
    Comparator
    TNBS colitis group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 and 20 μM · intraperitoneal · 7 days (doses on day 2 and day 6)As given in this study (rat).

    Source sentences

    Summary
    HNG treatment significantly ameliorated weight loss and macroscopic and microscopic scores.
    1 context sentence
    Summary · context
    Rats were divided into four groups as follows: Group 1 (n = 8): control; isotonic saline solution 0.1 ml/rat rectally, Group 2 (n = 8): TNBS colitis; 0.1 ml of a 2.5% (w/v) TNBS solution in 50% ethanol rectally, Group 3 (n = 8): 10 μM HNG, and Group 4 (n = 8): 20 μM HNG intraperitoneal (ip) on day 2…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, HNG treatment significantly ameliorated the microscopic score.

    In plain wordsIn rats with induced colitis, HNG treatment improved the microscopic damage score of the colon.

    Peptide
    Humanin
    Outcome
    DecreaseMicroscopic colitis score
    Study

    ratn: not reported in source

    TNBS-induced colitis
    Comparator
    TNBS colitis group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 and 20 μM · intraperitoneal · 7 days (doses on day 2 and day 6)As given in this study (rat).

    Source sentences

    Summary
    HNG treatment significantly ameliorated weight loss and macroscopic and microscopic scores.
    1 context sentence
    Summary · context
    Rats were divided into four groups as follows: Group 1 (n = 8): control; isotonic saline solution 0.1 ml/rat rectally, Group 2 (n = 8): TNBS colitis; 0.1 ml of a 2.5% (w/v) TNBS solution in 50% ethanol rectally, Group 3 (n = 8): 10 μM HNG, and Group 4 (n = 8): 20 μM HNG intraperitoneal (ip) on day 2…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, HNG treatment was associated with inhibition of colonic TNF-α mRNA expression compared with TNBS alone.

    In plain wordsIn rats with induced colitis, HNG treatment lowered the inflammation signal TNF-α in the colon compared with untreated colitis.

    Peptide
    Humanin
    Outcome
    DecreaseColonic TNF-α mRNA expression
    Study

    ratn: not reported in source

    TNBS-induced colitis
    Comparator
    TNBS colitis group
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    10 and 20 μM · intraperitoneal · 7 days (doses on day 2 and day 6)As given in this study (rat).

    Source sentences

    Summary
    HNG treatment was associated with an inhibition of mRNA expression of TNF-α and IL-1β, and a decrease in caspase-3 activities in colon tissues in group III and IV when compared to group II.
    1 context sentence
    Summary · context
    Rats were divided into four groups as follows: Group 1 (n = 8): control; isotonic saline solution 0.1 ml/rat rectally, Group 2 (n = 8): TNBS colitis; 0.1 ml of a 2.5% (w/v) TNBS solution in 50% ethanol rectally, Group 3 (n = 8): 10 μM HNG, and Group 4 (n = 8): 20 μM HNG intraperitoneal (ip) on day 2…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, HNG treatment was associated with inhibition of colonic IL-1β mRNA expression compared with TNBS alone.

    In plain wordsIn rats with induced colitis, HNG treatment lowered the inflammation signal IL-1β in the colon compared with untreated colitis.

    Peptide
    Humanin
    Outcome
    DecreaseColonic IL-1β mRNA expression
    Study

    ratn: not reported in source

    TNBS-induced colitis
    Comparator
    TNBS colitis group
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    10 and 20 μM · intraperitoneal · 7 days (doses on day 2 and day 6)As given in this study (rat).

    Source sentences

    Summary
    HNG treatment was associated with an inhibition of mRNA expression of TNF-α and IL-1β, and a decrease in caspase-3 activities in colon tissues in group III and IV when compared to group II.
    1 context sentence
    Summary · context
    Rats were divided into four groups as follows: Group 1 (n = 8): control; isotonic saline solution 0.1 ml/rat rectally, Group 2 (n = 8): TNBS colitis; 0.1 ml of a 2.5% (w/v) TNBS solution in 50% ethanol rectally, Group 3 (n = 8): 10 μM HNG, and Group 4 (n = 8): 20 μM HNG intraperitoneal (ip) on day 2…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, HNG treatment was associated with a decrease in colonic caspase-3 activity compared with TNBS alone.

    In plain wordsIn rats with induced colitis, HNG treatment lowered a cell death marker, caspase-3, in the colon compared with untreated colitis.

    Peptide
    Humanin
    Outcome
    DecreaseColonic caspase-3 activity
    Study

    ratn: not reported in source

    TNBS-induced colitis
    Comparator
    TNBS colitis group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 and 20 μM · intraperitoneal · 7 days (doses on day 2 and day 6)As given in this study (rat).

    Source sentences

    Summary
    HNG treatment was associated with an inhibition of mRNA expression of TNF-α and IL-1β, and a decrease in caspase-3 activities in colon tissues in group III and IV when compared to group II.
    1 context sentence
    Summary · context
    Rats were divided into four groups as follows: Group 1 (n = 8): control; isotonic saline solution 0.1 ml/rat rectally, Group 2 (n = 8): TNBS colitis; 0.1 ml of a 2.5% (w/v) TNBS solution in 50% ethanol rectally, Group 3 (n = 8): 10 μM HNG, and Group 4 (n = 8): 20 μM HNG intraperitoneal (ip) on day 2…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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