The follicle-stimulating hormone (FSH) and luteinizing hormone (LH) response to a gonadotropin-releasing hormone analogue test in healthy prepubertal girls aged 10 months to 6 years.

Vestergaard ET, Schjørring ME, Kamperis K, Petersen KK, Rittig S, Juul A, Kristensen K, Birkebæk NH

European journal of endocrinology27 Mar 2017Cited by 12 (Europe PMC)

PMID28348072DOI10.1530/eje-17-0042PepBankPUB-28348072

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanObservational studyActivity measurement
In healthy prepubertal girls, serum LH 30 minutes after gonadorelin injection averaged 5.2 IU/L at 0.8-3.0 years and 2.9 IU/L at 3.0-5.9 years.
In plain wordsIn healthy young girls, LH rose 30 minutes after a gonadorelin injection to about 5.2 IU/L in younger and 2.9 IU/L in older girls.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicable30-min LH response to gonadorelin
Study
n = 48
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (human).
Measurements
LH response
5.2 IU/L
girls aged 0.8-3.0 years
LH response
2.9 IU/L
girls aged 3.0-5.9 years
Source sentences
Summary
The 30-min LH responses (mean ± 2 s.d.) were 5.2 ± 4.0 and 2.9 ± 2.5 IU/L and the FSH responses were 23.3 ± 16.2 and 14.5 ± 10.3 IU/L in girls aged 0.8-3.0 years and 3.0-5.9 years respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-eight healthy normal-weight girls aged 3.5 ± 0.2 years (range: 0.8-5.9 years) were included.
Summary · context
Serum concentrations of LH and FSH were measured before and 30 min after the gonadorelin injection.
Report a problemFND-2834807201
02HumanObservational studyActivity measurement
In healthy prepubertal girls, serum FSH 30 minutes after gonadorelin injection averaged 23.3 IU/L at 0.8-3.0 years and 14.5 IU/L at 3.0-5.9 years.
In plain wordsIn healthy young girls, FSH rose 30 minutes after a gonadorelin injection to about 23.3 IU/L in younger and 14.5 IU/L in older girls.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicable30-min FSH response to gonadorelin
Study
n = 48
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (human).
Measurements
FSH response
23.3 IU/L
girls aged 0.8-3.0 years
FSH response
14.5 IU/L
girls aged 3.0-5.9 years
Source sentences
Summary
The 30-min LH responses (mean ± 2 s.d.) were 5.2 ± 4.0 and 2.9 ± 2.5 IU/L and the FSH responses were 23.3 ± 16.2 and 14.5 ± 10.3 IU/L in girls aged 0.8-3.0 years and 3.0-5.9 years respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-eight healthy normal-weight girls aged 3.5 ± 0.2 years (range: 0.8-5.9 years) were included.
Summary · context
Serum concentrations of LH and FSH were measured before and 30 min after the gonadorelin injection.
Report a problemFND-2834807202
03HumanObservational studyActivity measurement
In healthy prepubertal girls, the upper cut-off limit of the stimulated LH response was 9.2 IU/L under 3 years and 5.3 IU/L at 3-6 years.
In plain wordsIn healthy young girls, the upper limit of a normal LH response to gonadorelin was 9.2 IU/L under age 3 and 5.3 IU/L at 3-6.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableUpper cut-off limits for stimulated LH
Study
n = 48
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (human).
Measurements
Upper cut-off LH
9.2 IU/L
girls under 3 years
Upper cut-off LH
5.3 IU/L
girls aged 3-6 years
Source sentences
Summary
This corresponds to upper cut-off limits for LH of 9.2 IU/L (<3 years) and 5.3 IU/L (3-6 years).
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-eight healthy normal-weight girls aged 3.5 ± 0.2 years (range: 0.8-5.9 years) were included.
Summary · context
Serum concentrations of LH and FSH were measured before and 30 min after the gonadorelin injection.
Report a problemFND-2834807203
04HumanObservational studyActivity measurement
In healthy prepubertal girls, the stimulated LH/FSH ratio after gonadorelin was 0.23.
In plain wordsIn healthy young girls, the LH to FSH ratio after gonadorelin was about 0.23.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableStimulated LH/FSH ratio
Study
n = 48
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (human).
Measurements
Stimulated LH/FSH ratio
0.23 ratio
healthy prepubertal girls
Source sentences
Summary
The stimulated LH/FSH ratio was 0.23 ± 0.19 (range 0.06-0.43) and did not correlate with age.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-eight healthy normal-weight girls aged 3.5 ± 0.2 years (range: 0.8-5.9 years) were included.
Summary · context
Serum concentrations of LH and FSH were measured before and 30 min after the gonadorelin injection.
Report a problemFND-2834807204
05HumanObservational studyActivity measurement
In healthy prepubertal girls, the stimulated LH/FSH ratio after gonadorelin did not correlate with age.
In plain wordsIn healthy young girls, the LH to FSH ratio after gonadorelin did not change with age.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeCorrelation of stimulated LH/FSH ratio with age
Study
n = 48
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (human).
Source sentences
Summary
The stimulated LH/FSH ratio was 0.23 ± 0.19 (range 0.06-0.43) and did not correlate with age.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-eight healthy normal-weight girls aged 3.5 ± 0.2 years (range: 0.8-5.9 years) were included.
Summary · context
Serum concentrations of LH and FSH were measured before and 30 min after the gonadorelin injection.
Report a problemFND-2834807205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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