The Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling Pathway.

Huang J, Li Y, Zhang J, Liu Y, Lu Q

International heart journal17 Mar 2017Cited by 17 (Europe PMC)

PMID28321024DOI10.1536/ihj.16-241PepBankPUB-28321024

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial ischemia/reperfusion injury, hexarelin improved cardiac systolic function.
In plain wordsIn rats with heart injury after blocked blood flow, hexarelin improved how well the heart pumped.
Peptide
Hexarelin
Outcome
IncreaseCardiac systolic function
Study
ratn: not reported in source
Rat in vivo myocardial ischemia/reperfusion (left coronary artery ligation)
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
100 μg/kg·day · subcutaneous · 7 daysAs given in this study (rat).
Source sentences
Summary
Our study showed that hexarelin treatment improved cardiac systolic function, decreased malondialdehyde production, and increased the number of surviving cardiomyocytes.
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo hearts of male SD rats underwent 30 minutes of ischemia by left coronary artery ligation followed by reperfusion. The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.
Report a problemFND-2832102401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial ischemia/reperfusion injury, hexarelin decreased malondialdehyde production.
In plain wordsIn rats with heart injury after blocked blood flow, hexarelin lowered a marker of oxidative damage.
Peptide
Hexarelin
Outcome
DecreaseMalondialdehyde production
Study
ratn: not reported in source
Rat in vivo myocardial ischemia/reperfusion (left coronary artery ligation)
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
100 μg/kg·day · subcutaneous · 7 daysAs given in this study (rat).
Source sentences
Summary
Our study showed that hexarelin treatment improved cardiac systolic function, decreased malondialdehyde production, and increased the number of surviving cardiomyocytes.
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo hearts of male SD rats underwent 30 minutes of ischemia by left coronary artery ligation followed by reperfusion. The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.
Report a problemFND-2832102402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial ischemia/reperfusion injury, hexarelin increased the number of surviving cardiomyocytes.
In plain wordsIn rats with heart injury after blocked blood flow, hexarelin left more heart muscle cells alive.
Peptide
Hexarelin
Outcome
IncreaseNumber of surviving cardiomyocytes
Study
ratn: not reported in source
Rat in vivo myocardial ischemia/reperfusion (left coronary artery ligation)
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
100 μg/kg·day · subcutaneous · 7 daysAs given in this study (rat).
Source sentences
Summary
Our study showed that hexarelin treatment improved cardiac systolic function, decreased malondialdehyde production, and increased the number of surviving cardiomyocytes.
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo hearts of male SD rats underwent 30 minutes of ischemia by left coronary artery ligation followed by reperfusion. The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.
Report a problemFND-2832102403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial ischemia/reperfusion injury, the beneficial effects of hexarelin were slightly superior to those of equimolar ghrelin.
In plain wordsIn rats with heart injury after blocked blood flow, hexarelin worked slightly better than the same molar amount of ghrelin.
Peptide
Hexarelin
Outcome
IncreaseCardioprotective effect versus equimolar ghrelin
Study
ratn: not reported in source
Rat in vivo myocardial ischemia/reperfusion (left coronary artery ligation)
Comparator
Ghrelin (equimolar)
Outcome group
Heart function · Cardiovascular
Studied dose
100 μg/kg·day · subcutaneous · 7 daysAs given in this study (rat).
Source sentences
Summary
The beneficial effects of hexarelin treatment were slightly superior to those of equimolar ghrelin treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo hearts of male SD rats underwent 30 minutes of ischemia by left coronary artery ligation followed by reperfusion. The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.
Report a problemFND-2832102404
05AnimalAnimal study (in vivo)Mechanism
In rats with myocardial ischemia/reperfusion injury, hexarelin down-regulated IL-1β expression in the myocardium.
In plain wordsIn rats with heart injury after blocked blood flow, hexarelin lowered the inflammation signal IL-1β in heart tissue.
Peptide
Hexarelin
Outcome
DecreaseIL-1β expression in I/R myocardium
Study
ratn: not reported in source
Rat in vivo myocardial ischemia/reperfusion (left coronary artery ligation)
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
100 μg/kg·day · subcutaneous · 7 daysAs given in this study (rat).
Source sentences
Summary
We meanwhile confirmed that hexarelin induced down-regulation of IL-1β expression and up-regulation of IL-1Ra expression in I/R myocardium, which could be neutralized by the GHSR antagonist [D-Lys3]-growth hormone releasing peptide-6 ([D-Lys3]-GHRP-6).
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo hearts of male SD rats underwent 30 minutes of ischemia by left coronary artery ligation followed by reperfusion. The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.
Report a problemFND-2832102405
06AnimalAnimal study (in vivo)Mechanism
In rats with myocardial ischemia/reperfusion injury, hexarelin up-regulated IL-1Ra expression in the myocardium.
In plain wordsIn rats with heart injury after blocked blood flow, hexarelin raised IL-1Ra, a natural blocker of IL-1, in heart tissue.
Peptide
Hexarelin
Outcome
IncreaseIL-1Ra expression in I/R myocardium
Study
ratn: not reported in source
Rat in vivo myocardial ischemia/reperfusion (left coronary artery ligation)
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
100 μg/kg·day · subcutaneous · 7 daysAs given in this study (rat).
Source sentences
Summary
We meanwhile confirmed that hexarelin induced down-regulation of IL-1β expression and up-regulation of IL-1Ra expression in I/R myocardium, which could be neutralized by the GHSR antagonist [D-Lys3]-growth hormone releasing peptide-6 ([D-Lys3]-GHRP-6).
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo hearts of male SD rats underwent 30 minutes of ischemia by left coronary artery ligation followed by reperfusion. The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.
Report a problemFND-2832102406
07AnimalAnimal study (in vivo)Mechanism
In rats with myocardial ischemia/reperfusion injury, the GHSR antagonist [D-Lys3]-GHRP-6 neutralized the hexarelin-induced changes in IL-1β and IL-1Ra expression.
In plain wordsIn rats with heart injury after blocked blood flow, a receptor blocker cancelled hexarelin's effects on IL-1β and IL-1Ra.
Peptide
Hexarelin
Outcome
Not applicableBlockade of hexarelin IL-1 effects by GHSR antagonist
Study
ratn: not reported in source
Rat in vivo myocardial ischemia/reperfusion (left coronary artery ligation)
Comparator
[D-Lys3]-GHRP-6 (GHSR antagonist)
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
100 μg/kg·day · subcutaneous · 7 daysAs given in this study (rat).
Source sentences
Summary
We meanwhile confirmed that hexarelin induced down-regulation of IL-1β expression and up-regulation of IL-1Ra expression in I/R myocardium, which could be neutralized by the GHSR antagonist [D-Lys3]-growth hormone releasing peptide-6 ([D-Lys3]-GHRP-6).
1 context sentence(design, population, supporting numbers)
Summary · context
In vivo hearts of male SD rats underwent 30 minutes of ischemia by left coronary artery ligation followed by reperfusion. The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.
Report a problemFND-2832102407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Journal Article

MeSH terms

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